Seroatlas · Human Serome Atlas

TAF11L2

TATA-box binding protein associated factor 11 like protein 2

Also known as: TFKL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NLC8
Gene
TAF11L2
Ensembl
ENSG00000284373
Chromosome
5
Canonical length
198 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein heterodimerization activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>A6NLC8|TAF11L2
     1  METGRQTGVS AEMFAMPRDL KGSKKDGIPE DLDGNLEEPR DQEGELRSED VMDLTEGDNE
    61  ASASAPPAAK RRKTDTKGKK ERKPTVDAEE AQRMTTLLSA MSEEQLSRYE VCRRSAFPKA
   121  CIAGLMRSIT GRSVSENVAI AMAGIAKVFV GEVVEEALDV CEMWGEMPPL QPKHLREAVR
   181  RLKPKGLFPN SNYKKIMF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF11L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
0.1 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.4 nTPM
  • hippocampal formation: 0.2 nTPM
  • basal ganglia: 0.1 nTPM
  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM
  • cerebellum: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF11L2 as an antibody target. Whether an autoantibody or antibody against TAF11L2 could matter depends on whether native TAF11L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF11L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF11L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TAF11L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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