Seroatlas · Human Serome Atlas

TAF11L12

TATA-box-binding protein-associated factor 11-like protein 12

Also known as: TFKLL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1W2PPW3
Gene
TAF11L12
Ensembl
ENSG00000249156
Chromosome
5
Canonical length
197 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein heterodimerization activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>A0A1W2PPW3|TAF11L12
     1  METGRQRGAS AEMFAMPQGL KGSNKDGIPE DLDGNLEEPR DQESELRSQD VMDLTEGDNE
    61  ASASAPPAAK RQKTDTKGKK ERKPTVDAEE AQMTTLLYAM SEEQLSRYEV CRRSAFPKAR
   121  IAALMQSITG RSVSENTAIA MAGIAKVLVG EVVEEALDVC EMWGETPPLQ PKHLREAVRR
   181  LKPKGLFPNS NYKKIMF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF11L12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
0 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM
  • blood vessel: 0 nTPM

Single-cell type

  • epididymal principal cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 0.5 nTPM
  • basal ganglia: 0.3 nTPM
  • hippocampal formation: 0.3 nTPM
  • white matter: 0.2 nTPM
  • amygdala: 0 nTPM
  • cerebellum: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF11L12 as an antibody target. Whether an autoantibody or antibody against TAF11L12 could matter depends on whether native TAF11L12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF11L12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF11L12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TAF11L12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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