Seroatlas · Human Serome Atlas

NEURL3

E3 ubiquitin-protein ligase NEURL3

Also known as: Lincr, LOC93082, NEUL3_HUMAN, RNF132

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EH8
Gene: NEURL3
Ensembl: ENSG00000163121
Chromosome: 2
Canonical length: 262 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Enables ubiquitin protein ligase activity. Involved in positive regulation of proteasomal protein catabolic process. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q96EH8|NEURL3
     1  MGAQLCFEAN AKAPREALRF HAEAKGAQVR LDTRGCIAHR RTTFHDGIVF SQRPVRLGER
    61  VALRVLREES GWCGGLRVGF TRLDPACVSV PSLPPFLCPD LEEQSPTWAA VLPEGCALTG
   121  DLVRFWVDRR GCLFAKVNAG CRLLLREGVP VGAPLWAVMD VYGTTKAIEL LDPTASRLPT
   181  PMPWDLSNKA VPEPKATPGE ECAICFYHAA NTRLVPCGHT YFCRYCAWRV FSDTAKCPVC
   241  RWQIEAVAPA QGPPALRVEE GS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEURL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 29 nTPM
pancreas: 25 nTPM
kidney: 15 nTPM
thymus: 4.4 nTPM
prostate: 3.8 nTPM
liver: 2.5 nTPM

Single-cell type

pancreatic duct cells: 181 nCPM
salivary duct cells: 98 nCPM
lacrimal acinar cells: 51 nCPM
conjunctival goblet cells: 35 nCPM
cholangiocytes: 21 nCPM
pancreatic acinar cells: 18 nCPM

Immune cell

total PBMC: 0.5 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 1 nTPM
white matter: 1 nTPM
basal ganglia: 0.9 nTPM
pons: 0.9 nTPM
amygdala: 0.8 nTPM
medulla oblongata: 0.8 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEURL3 as an antibody target. Whether an autoantibody or antibody against NEURL3 could matter depends on whether native NEURL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEURL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NEURL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...