Solute carrier family 13

Definition

Integral membrane proteins that mediate the intake of a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters) can be grouped, on the basis of sequence and functional similarities into a number of distinct families. The SLC13 family consists mainly of dicarboxylate and sulfate transporters [[cite:PMID:16211368], [cite:PMID:23506872]], and includes of the following proteins: Mammalian sodium/sulphate cotransporter PMID:7690140. Mammalian renal sodium/dicarboxylate cotransporter PMID:8967342, which transports succinate and citrate. Mammalian sodium/citrate cotransporter PMID:8967342, which mediates the entry of citrate into cells, which is a critical participant of biochemical pathways [[cite:PMID:33597751], [cite:PMID:30054523]]. Mammalian intestinal sodium/dicarboxylate cotransporter. Chlamydomonas reinhardtii putative sulphur deprivation response regulator SAC1 PMID:8641280. These transporters are proteins of from 430 to 620 amino acids which are highly hydrophobic and which probably contain about 12 transmembrane regions.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• SLC13A1
• SLC13A2
• SLC13A3
• SLC13A4
• SLC13A5