Seroatlas · Human Serome Atlas

SLC13A4

Solute carrier family 13 member 4

Also known as: S13A4_HUMAN, SUT-1, SUT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKG4
Gene: SLC13A4
Ensembl: ENSG00000164707
Chromosome: 7
Canonical length: 626 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables sodium:sulfate symporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

626 residues, UniProt reviewed canonical sequence.

>Q9UKG4|SLC13A4
     1  MGLLQGLLRV RKLLLVVCVP LLLLPLPVLH PSSEASCAYV LIVTAVYWVS EAVPLGAAAL
    61  VPAFLYPFFG VLRSNEVAAE YFKNTTLLLV GVICVAAAVE KWNLHKRIAL RMVLMAGAKP
   121  GMLLLCFMCC TTLLSMWLSN TSTTAMVMPI VEAVLQELVS AEDEQLVAGN SNTEEAEPIS
   181  LDVKNSQPSL ELIFVNEESN ADLTTLMHNE NLNGVPSITN PIKTANQHQG KKQHPSQEKP
   241  QVLTPSPRKQ KLNRKYRSHH DQMICKCLSL SISYSATIGG LTTIIGTSTS LIFLEHFNNQ
   301  YPAAEVVNFG TWFLFSFPIS LIMLVVSWFW MHWLFLGCNF KETCSLSKKK KTKREQLSEK
   361  RIQEEYEKLG DISYPEMVTG FFFILMTVLW FTREPGFVPG WDSFFEKKGY RTDATVSVFL
   421  GFLLFLIPAK KPCFGKKNDG ENQEHSLGTE PIITWKDFQK TMPWEIVILV GGGYALASGS
   481  KSSGLSTWIG NQMLSLSSLP PWAVTLLACI LVSIVTEFVS NPATITIFLP ILCSLSETLH
   541  INPLYTLIPV TMCISFAVML PVGNPPNAIV FSYGHCQIKD MVKAGLGVNV IGLVIVMVAI
   601  NTWGVSLFHL DTYPAWARVS NITDQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC13A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 1,461 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 1,461 nTPM
placenta: 55 nTPM
testis: 3.9 nTPM
retina: 2.3 nTPM
tonsil: 2 nTPM
esophagus: 1.5 nTPM

Single-cell type

choroid plexus epithelial cells: 1,851 nCPM
syncytiotrophoblasts: 1,149 nCPM
cytotrophoblasts: 307 nCPM
cardiomyocytes: 163 nCPM
esophageal apical cells: 96 nCPM
epicardial cells: 86 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1,926 nTPM
hippocampal formation: 94 nTPM
thalamus: 28 nTPM
cerebellum: 19 nTPM
cerebral cortex: 6.7 nTPM
midbrain: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.82
gnomAD missense Z: 2.01
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC13A4 as an antibody target. Whether an autoantibody or antibody against SLC13A4 could matter depends on whether native SLC13A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC13A4 is annotated at the cell surface, where native SLC13A4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC13A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...