Seroatlas · Human Serome Atlas

SLC13A1

Solute carrier family 13 member 1

Also known as: NAS1, NaSi-1, S13A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZW2
Gene: SLC13A1
Ensembl: ENSG00000081800
Chromosome: 7
Canonical length: 595 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is an apical membrane Na(+)-sulfate cotransporter involved in sulfate homeostasis in the kidney. Defects in this gene lead to many pathophysiologic problems. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

595 residues, UniProt reviewed canonical sequence.

>Q9BZW2|SLC13A1
     1  MKFFSYILVY RRFLFVVFTV LVLLPLPIVL HTKEAECAYT LFVVATFWLT EALPLSVTAL
    61  LPSLMLPMFG IMPSKKVASA YFKDFHLLLI GVICLATSIE KWNLHKRIAL KMVMMVGVNP
   121  AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI AEAVVQQIIN AEAEVEATQM TYFNGSTNHG
   181  LEIDESVNGH EINERKEKTK PVPGYNNDTG KISSKVELEK NSGMRTKYRT KKGHVTRKLT
   241  CLCIAYSSTI GGLTTITGTS TNLIFAEYFN TRYPDCRCLN FGSWFTFSFP AALIILLLSW
   301  IWLQWLFLGF NFKEMFKCGK TKTVQQKACA EVIKQEYQKL GPIRYQEIVT LVLFIIMALL
   361  WFSRDPGFVP GWSALFSEYP GFATDSTVAL LIGLLFFLIP AKTLTKTTPT GEIVAFDYSP
   421  LITWKEFQSF MPWDIAILVG GGFALADGCE ESGLSKWIGN KLSPLGSLPA WLIILISSLM
   481  VTSLTEVASN PATITLFLPI LSPLAEAIHV NPLYILIPST LCTSFAFLLP VANPPNAIVF
   541  SYGHLKVIDM VKAGLGVNIV GVAVVMLGIC TWIVPMFDLY TYPSWAPAMS NETMP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC13A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

kidney: 76 nTPM
small intestine: 11 nTPM
gallbladder: 7.1 nTPM
colon: 0.2 nTPM
duodenum: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

proximal tubule cells: 767 nCPM
enterocytes: 213 nCPM
renal connecting tubule cells: 37 nCPM
paneth cells: 19 nCPM
enteric stem cells: 16 nCPM
distal convoluted tubule cells: 15 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0.2 nTPM
cerebellum: 0.2 nTPM
cerebral cortex: 0.2 nTPM
choroid plexus: 0.2 nTPM
hippocampal formation: 0.2 nTPM
hypothalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC13A1 as an antibody target. Whether an autoantibody or antibody against SLC13A1 could matter depends on whether native SLC13A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC13A1 is annotated at the cell surface, where native SLC13A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC13A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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