CDP-alcohol phosphatidyltransferase

Definition

A number of phosphatidyltransferases, which are all involved in phospholipid biosynthesis and that share the property of catalysing the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond share a conserved sequence region [[cite:PMID:3031032], [cite:PMID:1848238]]. These enzymes are proteins of 200 to 400 amino acid residues, including EPT1 from yeast, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferases from bacteria, CDP-diacylglycerol--serine O-phosphatidyltransferase from animals, among others. Also included in this entry is cardiolipin (CL) synthase (CMP-forming)/mitochondrial hydrolase fusion protein from S.pombe, a tandem fusion protein with a mitochondrial hydrolase. The CL synthase is essential for this organism PMID:29958934.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• CDIPT
• CEPT1
• CHPT1
• CRLS1
• SELENOI