Seroatlas · Human Serome Atlas

CEPT1

Choline/ethanolaminephosphotransferase 1

Also known as: CEPT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6K0
Gene: CEPT1
Ensembl: ENSG00000134255
Chromosome: 1
Canonical length: 416 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins, Transporters
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene codes for a choline/ethanolaminephosphotransferase, which functions in the synthesis of choline- or ethanolamine- containing phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>Q9Y6K0|CEPT1
     1  MSGHRSTRKR CGDSHPESPV GFGHMSTTGC VLNKLFQLPT PPLSRHQLKR LEEHRYQSAG
    61  RSLLEPLMQG YWEWLVRRVP SWIAPNLITI IGLSINICTT ILLVFYCPTA TEQAPLWAYI
   121  ACACGLFIYQ SLDAIDGKQA RRTNSSSPLG ELFDHGCDSL STVFVVLGTC IAVQLGTNPD
   181  WMFFCCFAGT FMFYCAHWQT YVSGTLRFGI IDVTEVQIFI IIMHLLAVIG GPPFWQSMIP
   241  VLNIQMKIFP ALCTVAGTIF SCTNYFRVIF TGGVGKNGST IAGTSVLSPF LHIGSVITLA
   301  AMIYKKSAVQ LFEKHPCLYI LTFGFVSAKI TNKLVVAHMT KSEMHLHDTA FIGPALLFLD
   361  QYFNSFIDEY IVLWIALVFS FFDLIRYCVS VCNQIASHLH IHVFRIKVST AHSNHH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEPT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

liver: 34 nTPM
lymph node: 30 nTPM
spleen: 26 nTPM
tonsil: 22 nTPM
appendix: 21 nTPM
adipose tissue: 20 nTPM

Single-cell type

adipocytes: 194 nCPM
cardiomyocytes: 143 nCPM
sertoli cells: 139 nCPM
kupffer cells: 138 nCPM
b-cells: 125 nCPM
myonuclei: 108 nCPM

Immune cell

non-classical monocyte: 30 nTPM
naive B-cell: 20 nTPM
memory B-cell: 20 nTPM
intermediate monocyte: 20 nTPM
myeloid DC: 13 nTPM
naive CD4 T-cell: 11 nTPM

Brain region

white matter: 19 nTPM
spinal cord: 15 nTPM
medulla oblongata: 14 nTPM
hypothalamus: 13 nTPM
pons: 13 nTPM
cerebellum: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 0.99
gnomAD missense Z: 2.5
DepMap mean gene effect: -0.44
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

diacylglycerol cholinephosphotransferase activity
ethanolaminephosphotransferase activity
metal ion binding
1-alkenyl-2-acylglycerol choline phosphotransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEPT1 as an antibody target. Whether an autoantibody or antibody against CEPT1 could matter depends on whether native CEPT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEPT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEPT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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