Seroatlas · Human Serome Atlas

CHPT1

Cholinephosphotransferase 1

Also known as: CHPT1_HUMAN, CPT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WUD6
Gene: CHPT1
Ensembl: ENSG00000111666
Chromosome: 12
Canonical length: 406 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables diacylglycerol cholinephosphotransferase activity. Involved in phosphatidylcholine biosynthetic process and platelet activating factor biosynthetic process. Is active in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q8WUD6|CHPT1
     1  MAAGAGAGSA PRWLRALSEP LSAAQLRRLE EHRYSAAGVS LLEPPLQLYW TWLLQWIPLW
    61  MAPNSITLLG LAVNVVTTLV LISYCPTATE EAPYWTYLLC ALGLFIYQSL DAIDGKQARR
   121  TNSCSPLGEL FDHGCDSLST VFMAVGASIA ARLGTYPDWF FFCSFIGMFV FYCAHWQTYV
   181  SGMLRFGKVD VTEIQIALVI VFVLSAFGGA TMWDYTIPIL EIKLKILPVL GFLGGVIFSC
   241  SNYFHVILHG GVGKNGSTIA GTSVLSPGLH IGLIIILAIM IYKKSATDVF EKHPCLYILM
   301  FGCVFAKVSQ KLVVAHMTKS ELYLQDTVFL GPGLLFLDQY FNNFIDEYVV LWMAMVISSF
   361  DMVIYFSALC LQISRHLHLN IFKTACHQAP EQVQVLSSKS HQNNMD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHPT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 147 nTPM

Expression across tissuesHPA

Tissue

liver: 147 nTPM
salivary gland: 123 nTPM
breast: 96 nTPM
parathyroid gland: 87 nTPM
heart muscle: 87 nTPM
duodenum: 83 nTPM

Single-cell type

late spermatids: 1,239 nCPM
salivary acinar cells: 703 nCPM
breast lactating cells: 538 nCPM
astrocytes: 521 nCPM
lacrimal acinar cells: 485 nCPM
late primary spermatocytes: 407 nCPM

Immune cell

basophil: 37 nTPM
eosinophil: 15 nTPM
NK-cell: 4.6 nTPM
memory B-cell: 4.4 nTPM
plasmacytoid DC: 3.7 nTPM
neutrophil: 3.1 nTPM

Brain region

thalamus: 60 nTPM
midbrain: 53 nTPM
spinal cord: 50 nTPM
medulla oblongata: 50 nTPM
basal ganglia: 47 nTPM
amygdala: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: 0.82
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHPT1 as an antibody target. Whether an autoantibody or antibody against CHPT1 could matter depends on whether native CHPT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHPT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHPT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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