Seroatlas · Human Serome Atlas

CDIPT

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Also known as: CDIPT_HUMAN, PIS, PIS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14735
Gene
CDIPT
Ensembl
ENSG00000103502
Chromosome
16
Canonical length
213 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Plasma membrane

OverviewNCBI Gene

Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>O14735|CDIPT
     1  MPDENIFLFV PNLIGYARIV FAIISFYFMP CCPLTASSFY LLSGLLDAFD GHAARALNQG
    61  TRFGAMLDML TDRCSTMCLL VNLALLYPGA TLFFQISMSL DVASHWLHLH SSVVRGSESH
   121  KMIDLSGNPV LRIYYTSRPA LFTLCAGNEL FYCLLYLFHF SEGPLVGSVG LFRMGLWVTA
   181  PIALLKSLIS VIHLITAARN MAALDAADRA KKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDIPT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
131 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 131 nTPM
  • liver: 108 nTPM
  • ovary: 104 nTPM
  • heart muscle: 99 nTPM
  • colon: 98 nTPM
  • blood vessel: 97 nTPM

Single-cell type

  • extravillous trophoblasts: 168 nCPM
  • cytotrophoblasts: 147 nCPM
  • migrating cytotrophoblasts: 125 nCPM
  • megakaryocytes: 99 nCPM
  • ovarian stromal cells: 89 nCPM
  • esophageal suprabasal cells: 89 nCPM

Immune cell

  • eosinophil: 29 nTPM
  • neutrophil: 21 nTPM
  • T-reg: 12 nTPM
  • basophil: 12 nTPM
  • NK-cell: 12 nTPM
  • memory CD8 T-cell: 9.1 nTPM

Brain region

  • pons: 88 nTPM
  • medulla oblongata: 86 nTPM
  • cerebellum: 86 nTPM
  • hypothalamus: 82 nTPM
  • midbrain: 80 nTPM
  • amygdala: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0.13
gnomAD missense Z
0.72
DepMap mean gene effect
-0.56
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDIPT as an antibody target. Whether an autoantibody or antibody against CDIPT could matter depends on whether native CDIPT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDIPT is annotated at the cell surface, where native CDIPT is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDIPT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDIPT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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