Seroatlas · Human Serome Atlas

ZXDB

Zinc finger X-linked protein ZXDB

Also known as: ZNF905, ZXDB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P98169
Gene: ZXDB
Ensembl: ENSG00000198455
Chromosome: X
Canonical length: 803 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The ZXDB gene is one of a pair of duplicated zinc finger genes on chromosome Xp11.21 (Greig et al., 1993 [PubMed 8268913]); see also ZXDA (MIM 300235).[supplied by OMIM, Jul 2010]

Canonical amino-acid sequenceUniProt

803 residues, UniProt reviewed canonical sequence.

>P98169|ZXDB
     1  MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLLRGP QDGGPGRRRE
    61  EASTASRGPG PSLLAPRTDQ PSGGGGGGGD DFFLVLLDPV GGDVETAGSG QAAGPVLREE
   121  AEEGPGLQGG ESGANPAGPT ALGPRCLSAV PTPAPISAPG PAAAFAGTVT IHNQDLLLRF
   181  ENGVLTLATP PPHAWEPGAA PAQQPGCLIA PQAGFPHAAH PGDCPELPPD LLLAEPAEPA
   241  PAPAPEEEAE GPAAALGPRG PLGSGPGVVL YLCPEAQCGQ TFAKKHQLKV HLLTHSSSQG
   301  QRPFKCPLGG CGWTFTTSYK LKRHLQSHDK LRPFGCPAEG CGKSFTTVYN LKAHMKGHEQ
   361  ENSFKCEVCE ESFPTQAKLS AHQRSHFEPE RPYQCAFSGC KKTFITVSAL FSHNRAHFRE
   421  QELFSCSFPG CSKQYDKACR LKIHLRSHTG ERPFLCDFDG CGWNFTSMSK LLRHKRKHDD
   481  DRRFMCPVEG CGKSFTRAEH LKGHSITHLG TKPFVCPVAG CCARFSARSS LYIHSKKHLQ
   541  DVDTWKSRCP ISSCNKLFTS KHSMKTHMVK RHKVGQDLLA QLEAANSLTP SSELTSQRQN
   601  DLSDAEIVSL FSDVPDSTSA ALLDTALVNS GILTIDVASV SSTLAGHLPA NNNNSVGQAV
   661  DPPSLMATSD PPQSLDTSLF FGTAATGFQQ SSLNMDEVSS VSVGPLGSLD SLAMKNSSPE
   721  PQALTPSSKL TVDTDALTPS STLCENSVSE LLTPTKAEWN VHPDSDFFGQ EGETQFGFPN
   781  AAGNHGSQKE TDLITVTGSS FLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZXDB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

liver: 14 nTPM
bone marrow: 7.7 nTPM
cerebellum: 5.8 nTPM
pancreas: 5.7 nTPM
parathyroid gland: 5.7 nTPM
smooth muscle: 5.3 nTPM

Single-cell type

epicardial cells: 27 nCPM
suprabasal keratinocytes: 26 nCPM
ocular epithelial cells: 24 nCPM
basal keratinocytes: 24 nCPM
epididymal basal cells: 22 nCPM
endometrial luminal cells: 20 nCPM

Immune cell

memory CD8 T-cell: 0.5 nTPM
naive CD4 T-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
memory B-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM

Brain region

cerebellum: 12 nTPM
hypothalamus: 11 nTPM
pons: 11 nTPM
white matter: 11 nTPM
midbrain: 11 nTPM
spinal cord: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.95
gnomAD missense Z: 0.96
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZXDB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZXDB as an antibody target. Whether an autoantibody or antibody against ZXDB could matter depends on whether native ZXDB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZXDB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZXDB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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