Seroatlas · Human Serome Atlas

ZUP1

Zinc finger-containing ubiquitin peptidase 1

Also known as: C6orf113, dJ412I7.3, ZUFSP, ZUP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96AP4
Gene: ZUP1
Ensembl: ENSG00000153975
Chromosome: 6
Canonical length: 578 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. """"""""""""""""""""""""""""""""endo cleavage) rather than by removing the terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers. [provided by RefSeq, Mar 2018]

Canonical amino-acid sequenceUniProt

578 residues, UniProt reviewed canonical sequence.

>Q96AP4|ZUP1
     1  MLSCNICGET VTSEPDMKAH LIVHMESEII CPFCKLSGVN YDEMCFHIET AHFEQNTLER
    61  NFERINTVQY GTSDNKKDNT LQCGMEVNSS ILSGCASNHP KNSAQNLTKD STLKHEGFYS
   121  ENLTESRKFL KSREKQSSLT EIKGSVYETT YSPPECPFCG KIEEHSEDME THVKTKHANL
   181  LDIPLEDCDQ PLYDCPMCGL ICTNYHILQE HVDLHLEENS FQQGMDRVQC SGDLQLAHQL
   241  QQEEDRKRRS EESRQEIEEF QKLQRQYGLD NSGGYKQQQL RNMEIEVNRG RMPPSEFHRR
   301  KADMMESLAL GFDDGKTKTS GIIEALHRYY QNAATDVRRV WLSSVVDHFH SSLGDKGWGC
   361  GYRNFQMLLS SLLQNDAYND CLKGMLIPCI PKIQSMIEDA WKEGFDPQGA SQLNNRLQGT
   421  KAWIGACEVY ILLTSLRVKC HIVDFHKSTG PLGTHPRLFE WILNYYSSEG EGSPKVVCTS
   481  KPPIYLQHQG HSRTVIGIEE KKNRTLCLLI LDPGCPSREM QKLLKQDIEA SSLKQLRKSM
   541  GNLKHKQYQI LAVEGALSLE EKLARRQASQ VFTAEKIP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZUP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 13 nTPM
duodenum: 9.8 nTPM
lymph node: 8.2 nTPM
tonsil: 8.1 nTPM
thymus: 7 nTPM
small intestine: 6.7 nTPM

Single-cell type

neutrophil progenitors: 54 nCPM
erythrocyte progenitors: 43 nCPM
oocytes: 41 nCPM
retinal ganglion cells: 39 nCPM
pituicytes/fscs: 35 nCPM
oligodendrocytes: 33 nCPM

Immune cell

basophil: 20 nTPM
T-reg: 12 nTPM
non-classical monocyte: 11 nTPM
naive B-cell: 11 nTPM
myeloid DC: 10 nTPM
memory B-cell: 9.5 nTPM

Brain region

cerebellum: 14 nTPM
white matter: 11 nTPM
cerebral cortex: 8.8 nTPM
thalamus: 8.7 nTPM
basal ganglia: 8.3 nTPM
hypothalamus: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZUP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZUP1 as an antibody target. Whether an autoantibody or antibody against ZUP1 could matter depends on whether native ZUP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZUP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZUP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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