Seroatlas · Human Serome Atlas

VWC2

Brorin

Also known as: PSST739, UNQ739, VWC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TAL6
Gene: VWC2
Ensembl: ENSG00000188730
Chromosome: 7
Canonical length: 325 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.[provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q2TAL6|VWC2
     1  MPSSTAMAVG ALSSSLLVTC CLMVALCSPS IPLEKLAQAP EQPGQEKREH ASRDGPGRVN
    61  ELGRPARDEG GSGRDWKSKS GRGLAGREPW SKLKQAWVSQ GGGAKAGDLQ VRPRGDTPQA
   121  EALAAAAQDA IGPELAPTPE PPEEYVYPDY RGKGCVDESG FVYAIGEKFA PGPSACPCLC
   181  TEEGPLCAQP ECPRLHPRCI HVDTSQCCPQ CKERKNYCEF RGKTYQTLEE FVVSPCERCR
   241  CEANGEVLCT VSACPQTECV DPVYEPDQCC PICKNGPNCF AETAVIPAGR EVKTDECTIC
   301  HCTYEEGTWR IERQAMCTRH ECRQM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VWC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 10 nTPM
heart muscle: 4.6 nTPM
ovary: 3.7 nTPM
amygdala: 2.2 nTPM
cerebral cortex: 1.9 nTPM
hypothalamus: 1.8 nTPM

Single-cell type

retinal ganglion cells: 518 nCPM
retinal bipolar cells: 413 nCPM
granulosa cells: 280 nCPM
rod photoreceptor cells: 270 nCPM
oligodendrocyte progenitor cells: 258 nCPM
brain excitatory neurons: 148 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 21 nTPM
thalamus: 11 nTPM
cerebral cortex: 7.8 nTPM
amygdala: 7.6 nTPM
midbrain: 6.2 nTPM
hypothalamus: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 0.97
gnomAD missense Z: 1.67
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VWC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZNF696

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VWC2 as an antibody target. Whether an autoantibody or antibody against VWC2 could matter depends on whether native VWC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VWC2 is annotated as secreted, so native VWC2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label VWC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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