Seroatlas · Human Serome Atlas

ZNF670

Zinc finger protein 670

Also known as: MGC12466, ZN670_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BS34
Gene
ZNF670
Ensembl
ENSG00000277462
Chromosome
1
Canonical length
389 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within lipid metabolic process. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q9BS34|ZNF670
     1  MDSVSFEDVA VAFTQEEWAL LDPSQKNLYR DVMQEIFRNL ASVGNKSEDQ NIQDDFKNPG
    61  RNLSSHVVER LFEIKEGSQY GETFSQDSNL NLNKKVSTGV KPCECSVCGK VFICHSALHR
   121  HILSHIGNKL FECEECPEKL YHCKQCGKAF ISLTSVDRHM VTHTSNGPYK GPVYEKPFDF
   181  PSVFQMPQST YTGEKTYKCK HCDKAFNYSS YLREHERTHT GEKPYACKKC GKSFTFSSSL
   241  RQHERSHTGE KPYECKECGK AFSRSTYLGI HERTHTGEKP YECIKCGKAF RCSRVLRVHE
   301  RTHSGEKPYE CKQCGKAFKY SSNLCEHERT HTGVKPYGCK ECGKSFTSSS ALRSHERTHT
   361  GEKPYECKKC GKAFSCSSSL RKHERAYMW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF670 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
2.4 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 2.4 nTPM
  • breast: 2.2 nTPM
  • ovary: 2.2 nTPM
  • endometrium: 2.1 nTPM
  • testis: 2.1 nTPM
  • retina: 2 nTPM

Single-cell type

  • early spermatids: 4.8 nCPM
  • paneth cells: 3.9 nCPM
  • late primary spermatocytes: 0.9 nCPM
  • late spermatids: 0.8 nCPM
  • epididymal basal cells: 0.5 nCPM
  • differentiating spermatogonia: 0.4 nCPM

Immune cell

  • memory B-cell: 2.1 nTPM
  • naive CD4 T-cell: 1.8 nTPM
  • naive B-cell: 1.5 nTPM
  • memory CD8 T-cell: 1.3 nTPM
  • myeloid DC: 1.3 nTPM
  • naive CD8 T-cell: 1.3 nTPM

Brain region

  • cerebellum: 7.5 nTPM
  • cerebral cortex: 4.2 nTPM
  • hippocampal formation: 3.6 nTPM
  • basal ganglia: 3.5 nTPM
  • hypothalamus: 3.5 nTPM
  • midbrain: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0
gnomAD missense Z
-0.46
DepMap mean gene effect
0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF670 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF670 as an antibody target. Whether an autoantibody or antibody against ZNF670 could matter depends on whether native ZNF670 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF670 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF670 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF670. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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