Seroatlas · Human Serome Atlas

ZNF783

Zinc finger protein 783

Also known as: DKFZp667J212, ZN783_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMS7
Gene: ZNF783
Ensembl: ENSG00000204946
Chromosome: 7
Canonical length: 546 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

546 residues, UniProt reviewed canonical sequence.

>Q6ZMS7|ZNF783
     1  MAEAAPARDP ETDKHTEDQS PSTPLPQPAA EKNSYLYSTE ITLWTVVAAI QALEKKVDSC
    61  LTRLLTLEGR TGTAEKKLAD CEKTAVEFGN QLEGKWAVLG TLLQEYGLLQ RRLENVENLL
   121  RNRNFWILRL PPGSKGEAPK VPVTFDDVAV YFSELEWGKL EDWQKELYKH VMRGNYETLV
   181  SLDYAISKPD ILTRIERGEE PCLDRWGQEK GNEVEVGRPR MMGTGLPPYP EHLTSPLSPA
   241  QEELKEGQAP KQQQDSEARV APAGPEAGGG VAIKTEAQSE DEMTPERLFL GVSRGQTECR
   301  IPRGPRNRPG GPSRHQAQGM PRVRAGEPRP PGASGETPRV LSRRRQRAFP CPDCGQSFRL
   361  KINLTIHQRT HVEEGRQEAP GRSPTSCGDS QAMLEPGEVV VPGPVIRWLP EEPEGRRSVA
   421  GGRALVGRRP AASKMYHCSE CLRFFQQRKS LLLHQRLHTG NGQGWPACPY CGKAFRRPSD
   481  LFRHQRIHTG ERPYQCPQCG RTFNRNHHLA VHMQTHARGQ VGPHFPAAPA RHGSLPLPWP
   541  SRKEEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF783 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

spleen: 12 nTPM
ovary: 12 nTPM
cervix: 9.9 nTPM
cerebellum: 9.4 nTPM
fallopian tube: 9.2 nTPM
prostate: 9.1 nTPM

Single-cell type

renal collecting duct intercalated cells: 25 nCPM
fibro-adipogenic progenitors: 19 nCPM
distal convoluted tubule cells: 19 nCPM
loop of henle epithelial cells: 18 nCPM
podocytes: 17 nCPM
renal connecting tubule cells: 17 nCPM

Immune cell

non-classical monocyte: 1.7 nTPM
naive B-cell: 1.2 nTPM
gdT-cell: 1 nTPM
plasmacytoid DC: 0.9 nTPM
MAIT T-cell: 0.8 nTPM
naive CD4 T-cell: 0.8 nTPM

Brain region

white matter: 12 nTPM
medulla oblongata: 11 nTPM
cerebral cortex: 11 nTPM
thalamus: 10 nTPM
midbrain: 10 nTPM
pons: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.25
DepMap mean gene effect: 0.06
DepMap dependency class: none

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF783 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZNF398

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF783 as an antibody target. Whether an autoantibody or antibody against ZNF783 could matter depends on whether native ZNF783 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF783 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF783 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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