Seroatlas · Human Serome Atlas

ZNF346

Zinc finger protein 346

Also known as: JAZ, Zfp346, ZN346_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UL40
Gene
ZNF346
Ensembl
ENSG00000113761
Chromosome
5
Canonical length
294 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

294 residues, UniProt reviewed canonical sequence.

>Q9UL40|ZNF346
     1  MEYPAPATVQ AADGGAAGPY SSSELLEGQE PDGVRFDRER ARRLWEAVSG AQPVGREEVE
    61  HMIQKNQCLF TNTQCKVCCA LLISESQKLA HYQSKKHANK VKRYLAIHGM ETLKGETKKL
   121  DSDQKSSRSK DKNQCCPICN MTFSSPVVAQ SHYLGKTHAK NLKLKQQSTK VEALHQNREM
   181  IDPDKFCSLC HATFNDPVMA QQHYVGKKHR KQETKLKLMA RYGRLADPAV TDFPAGKGYP
   241  CKTCKIVLNS IEQYQAHVSG FKHKNQSPKT VASSLGQIPM QRQPIQKDST TLED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF346 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 13 nTPM
  • ovary: 12 nTPM
  • retina: 10 nTPM
  • pituitary gland: 10 nTPM
  • thyroid gland: 9.8 nTPM
  • thymus: 9.4 nTPM

Single-cell type

  • myonuclei: 106 nCPM
  • cardiomyocytes: 89 nCPM
  • retinal amacrine cells: 79 nCPM
  • retinal ganglion cells: 73 nCPM
  • choroid plexus epithelial cells: 66 nCPM
  • thyrotrophs: 66 nCPM

Immune cell

  • NK-cell: 19 nTPM
  • naive B-cell: 8.4 nTPM
  • gdT-cell: 8.2 nTPM
  • naive CD8 T-cell: 7.4 nTPM
  • naive CD4 T-cell: 7.2 nTPM
  • eosinophil: 6.6 nTPM

Brain region

  • cerebellum: 34 nTPM
  • cerebral cortex: 25 nTPM
  • hypothalamus: 24 nTPM
  • amygdala: 24 nTPM
  • basal ganglia: 24 nTPM
  • hippocampal formation: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0.12
gnomAD missense Z
1.17
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF346 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF346 as an antibody target. Whether an autoantibody or antibody against ZNF346 could matter depends on whether native ZNF346 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF346 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF346 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF346. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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