Seroatlas · Human Serome Atlas

ZNF224

Zinc finger protein 224

Also known as: BMZF-2, KOX22, ZN224_HUMAN, ZNF255, ZNF27

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZL3
Gene: ZNF224
Ensembl: ENSG00000267680
Chromosome: 19
Canonical length: 707 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

707 residues, UniProt reviewed canonical sequence.

>Q9NZL3|ZNF224
     1  MTTFKEAMTF KDVAVVFTEE ELGLLDLAQR KLYRDVMLEN FRNLLSVGHQ AFHRDTFHFL
    61  REEKIWMMKT AIQREGNSGD KIQTEMETVS EAGTHQEWSF QQIWEKIASD LTRSQDLMIN
   121  SSQFSKEGDF PCQTEAGLSV IHTRQKSSQG NGYKPSFSDV SHFDFHQQLH SGEKSHTCDE
   181  CGKNFCYISA LRIHQRVHMG EKCYKCDVCG KEFSQSSHLQ THQRVHTGEK PFKCVECGKG
   241  FSRRSALNVH HKLHTGEKPY NCEECGKAFI HDSQLQEHQR IHTGEKPFKC DICGKSFCGR
   301  SRLNRHSMVH TAEKPFRCDT CDKSFRQRSA LNSHRMIHTG EKPYKCEECG KGFICRRDLY
   361  THHMVHTGEK PYNCKECGKS FRWASCLLKH QRVHSGEKPF KCEECGKGFY TNSQCYSHQR
   421  SHSGEKPYKC VECGKGYKRR LDLDFHQRVH TGEKLYNCKE CGKSFSRAPC LLKHERLHSG
   481  EKPFQCEECG KRFTQNSHLH SHQRVHTGEK PYKCEKCGKG YNSKFNLDMH QKVHTGERPY
   541  NCKECGKSFG WASCLLKHQR LHSGEKPFKC EECGKRFTQN SQLHSHQRVH TGEKPYKCDE
   601  CGKGFSWSST RLTHQRRHSR ETPLKCEQHG KNIVQNSFSK VQEKVHSVEK PYKCEDCGKG
   661  YNRRLNLDMH QRVHMGEKTW KCRECDMCFS QASSLRLHQN VHVGEKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF224 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

spleen: 23 nTPM
epididymis: 22 nTPM
skin: 21 nTPM
tonsil: 20 nTPM
lymph node: 19 nTPM
rectum: 18 nTPM

Single-cell type

adrenal cortex cells: 56 nCPM
choroid plexus epithelial cells: 45 nCPM
adrenal medulla cells: 43 nCPM
t-cells: 35 nCPM
oligodendrocytes: 34 nCPM
nk-cells: 34 nCPM

Immune cell

basophil: 32 nTPM
eosinophil: 13 nTPM
MAIT T-cell: 13 nTPM
naive CD4 T-cell: 13 nTPM
memory CD8 T-cell: 12 nTPM
T-reg: 12 nTPM

Brain region

choroid plexus: 21 nTPM
cerebellum: 21 nTPM
white matter: 21 nTPM
basal ganglia: 18 nTPM
pons: 17 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: 0.65
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF224 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DEPDC1A
WT1
DEPDC1
TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF224 as an antibody target. Whether an autoantibody or antibody against ZNF224 could matter depends on whether native ZNF224 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF224 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF224 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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