Seroatlas · Human Serome Atlas

ZNF3

Zinc finger protein 3

Also known as: A8-51, FLJ20216, HF.12, KOX25, PP838, Zfp113, ZNF3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17036
Gene: ZNF3
Ensembl: ENSG00000166526
Chromosome: 7
Canonical length: 446 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

446 residues, UniProt reviewed canonical sequence.

>P17036|ZNF3
     1  METQADLVSQ EPQALLDSAL PSKVPAFSDK DSLGDEMLAA ALLKAKSQEL VTFEDVAVYF
    61  IRKEWKRLEP AQRDLYRDVM LENYGNVFSL DRETRTENDQ EISEDTRSHG VLLGRFQKDI
   121  SQGLKFKEAY EREVSLKRPL GNSPGERLNR KMPDFGQVTV EEKLTPRGER SEKYNDFGNS
   181  FTVNSNLISH QRLPVGDRPH KCDECSKSFN RTSDLIQHQR IHTGEKPYEC NECGKAFSQS
   241  SHLIQHQRIH TGEKPYECSD CGKTFSCSSA LILHRRIHTG EKPYECNECG KTFSWSSTLT
   301  HHQRIHTGEK PYACNECGKA FSRSSTLIHH QRIHTGEKPY ECNECGKAFS QSSHLYQHQR
   361  IHTGEKPYEC MECGGKFTYS SGLIQHQRIH TGENPYECSE CGKAFRYSSA LVRHQRIHTG
   421  EKPLNGIGMS KSSLRVTTEL NIREST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 34 nTPM
bone marrow: 26 nTPM
ovary: 22 nTPM
epididymis: 21 nTPM
endometrium: 20 nTPM
small intestine: 20 nTPM

Single-cell type

endometrial ciliated cells: 59 nCPM
respiratory ciliated cells: 48 nCPM
ependymal cells: 44 nCPM
myonuclei: 40 nCPM
fallopian tube ciliated cells: 37 nCPM
enterocytes: 37 nCPM

Immune cell

eosinophil: 20 nTPM
NK-cell: 19 nTPM
MAIT T-cell: 17 nTPM
naive B-cell: 16 nTPM
naive CD8 T-cell: 15 nTPM
memory CD8 T-cell: 15 nTPM

Brain region

white matter: 35 nTPM
pons: 30 nTPM
medulla oblongata: 28 nTPM
midbrain: 27 nTPM
basal ganglia: 26 nTPM
thalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 1.31
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZNF212

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF3 as an antibody target. Whether an autoantibody or antibody against ZNF3 could matter depends on whether native ZNF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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