ZDHHC19
Palmitoyltransferase ZDHHC19
Also known as: MGC33345, ZDH19_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WVZ1
- Gene
- ZDHHC19
- Ensembl
- ENSG00000163958
- Chromosome
- 3
- Canonical length
- 309 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted membrane proteins
OverviewNCBI Gene
Enables protein-cysteine S-palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation and positive regulation of aggrephagy. Located in Golgi membrane; endoplasmic reticulum; and perinucleolar compartment. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
309 residues, UniProt reviewed canonical sequence.
>Q8WVZ1|ZDHHC19
1 MTLLTDATPL VKEPHPLPLV PRPWFLPSLF AAFNVVLLVF FSGLFFAFPC RWLAQNGEWA
61 FPVITGSLFV LTFFSLVSLN FSDPGILHQG SAEQGPLTVH VVWVNHGAFR LQWCPKCCFH
121 RPPRTYHCPW CNICVEDFDH HCKWVNNCIG HRNFRFFMLL VLSLCLYSGA MLVTCLIFLV
181 RTTHLPFSTD KAIAIVVAVS AAGLLVPLSL LLLIQALSVS SADRTYKGKC RHLQGYNPFD
241 QGCASNWYLT ICAPLGPKYM AEAVQLQRVV GPDWTSMPNL HPPMSPSALN PPAPTSGSLQ
301 SREGTPGAWLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZDHHC19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 47 nTPM
Expression across tissuesHPA
Tissue
- testis: 47 nTPM
- spleen: 1.5 nTPM
- adrenal gland: 0.7 nTPM
- liver: 0.5 nTPM
- appendix: 0.3 nTPM
- lung: 0.3 nTPM
Single-cell type
- late spermatids: 1,491 nCPM
- early spermatids: 482 nCPM
- neutrophils: 226 nCPM
- late primary spermatocytes: 152 nCPM
- peritubular myoid cells: 62 nCPM
- adrenal cortex cells: 53 nCPM
Immune cell
- memory B-cell: 2.5 nTPM
- naive B-cell: 2.4 nTPM
- neutrophil: 1.5 nTPM
- eosinophil: 1.2 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
Brain region
- hippocampal formation: 0.5 nTPM
- hypothalamus: 0.5 nTPM
- cerebral cortex: 0.3 nTPM
- medulla oblongata: 0.3 nTPM
- amygdala: 0.2 nTPM
- midbrain: 0.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.8
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 1.17
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZDHHC19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZDHHC19 as an antibody target. Whether an autoantibody or antibody against ZDHHC19 could matter depends on whether native ZDHHC19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZDHHC19 is annotated at the cell surface, where native ZDHHC19 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label ZDHHC19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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