Seroatlas · Human Serome Atlas

TEX38

Testis-expressed protein 38

Also known as: ATPAF1-AS1, C1orf223, LOC374973, TEX38_HUMAN, THEG4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PEX7
Gene: TEX38
Ensembl: ENSG00000186118
Chromosome: 1
Canonical length: 206 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>Q6PEX7|TEX38
     1  MDSQQEDLRF PGMWVSLYFG ILGLCSVITG GCIIFLHWRK NLRREEHAQQ WVEVMRAATF
    61  TYSPLLYWIN KRRRYGMNAA INTGPAPAVT KTETEVQNPD VLWDLDIPEG RSHADQDSNP
   121  KAEAPAPLQP ALQLAPQQPQ ARSPFPLPIF QEVPFAPPLC NLPPLLNHSV SYPLATCPER
   181  NVLFHSLLNL AQEDHSFNAK PFPSEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 377 nTPM

Expression across tissuesHPA

Tissue

testis: 377 nTPM
epididymis: 0.8 nTPM
pituitary gland: 0.8 nTPM
parathyroid gland: 0.6 nTPM
breast: 0.4 nTPM
prostate: 0.4 nTPM

Single-cell type

late spermatids: 8,497 nCPM
early spermatids: 2,549 nCPM
late primary spermatocytes: 1,135 nCPM
sertoli cells: 9.9 nCPM
leydig cells: 9.6 nCPM
peritubular myoid cells: 6.3 nCPM

Immune cell

eosinophil: 0.6 nTPM
MAIT T-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
gdT-cell: 0.2 nTPM
memory B-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

cerebellum: 1.4 nTPM
hypothalamus: 1.4 nTPM
basal ganglia: 1.3 nTPM
hippocampal formation: 1.3 nTPM
white matter: 1.3 nTPM
amygdala: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: 0.82
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

Testis-expressed sequence 38 protein
Testis highly expressed protein 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEX38 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZDHHC19

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX38 as an antibody target. Whether an autoantibody or antibody against TEX38 could matter depends on whether native TEX38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX38 is annotated at the cell surface, where native TEX38 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TEX38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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