Seroatlas · Human Serome Atlas

ZDHHC11

Palmitoyltransferase ZDHHC11

Also known as: FLJ13153, ZDH11_HUMAN, ZNF399

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8X9
Gene: ZDHHC11
Ensembl: ENSG00000188818
Chromosome: 5
Canonical length: 412 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Enables signaling adaptor activity. Involved in antiviral innate immune response and positive regulation of defense response to virus by host. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>Q9H8X9|ZDHHC11
     1  MDTRSGSQCS VTPEAILNNE KLVLPPRISR VNGWSLPLHY FQVVTWAVFV GLSSATFGIF
    61  IPFLPHAWKY IAYVVTGGIF SFHLVVHLIA SCIDPADSNV RLMKNYSQPM PLFDRSKHAH
   121  VIQNQFCHLC KVTVNKKTKH CISCNKCVSG FDHHCKWINN CVGSRNYWFF FSTVASATAG
   181  MLCLIAILLY VLVQYLVNPG VLRTDPRYED VKNMNTWLLF LPLFPVQVQT LIVVIIGMLV
   241  LLLDFLGLVH LGQLLIFHIY LKAKKMTTFE YLINNRKEES SKHQAVRKDP YVQMDKGVLQ
   301  QGAGALGSSA QGVKAKSSLL IHKHLCHFCT SVNQDGDSTA REGDEDPCPS ALGAKARNSR
   361  LICRRLCQFS TRVHPDGGSM AQEADDAPSI STLGLQQETT EPMKTDSAES ED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 15 nTPM
choroid plexus: 15 nTPM
pituitary gland: 12 nTPM
testis: 9.7 nTPM
heart muscle: 8.5 nTPM
hippocampal formation: 7.3 nTPM

Single-cell type

ependymal cells: 133 nCPM
thyrotrophs: 99 nCPM
somatotrophs: 78 nCPM
lactotrophs: 74 nCPM
choroid plexus epithelial cells: 71 nCPM
endometrial ciliated cells: 61 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 43 nTPM
cerebral cortex: 37 nTPM
midbrain: 32 nTPM
pons: 30 nTPM
medulla oblongata: 29 nTPM
basal ganglia: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: -0.92
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZDHHC11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC11 as an antibody target. Whether an autoantibody or antibody against ZDHHC11 could matter depends on whether native ZDHHC11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZDHHC11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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