Seroatlas · Human Serome Atlas

YIPF6

Protein YIPF6

Also known as: FinGER6, MGC21416, YIPF6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EC8
Gene: YIPF6
Ensembl: ENSG00000181704
Chromosome: X
Canonical length: 236 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable identical protein binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to act upstream of or within intestinal epithelial cell development. Located in Golgi apparatus subcompartment and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q96EC8|YIPF6
     1  MAEAEESPGD PGTASPRPLF AGLSDISISQ DIPVEGEITI PMRSRIREFD SSTLNESVRN
    61  TIMRDLKAVG KKFMHVLYPR KSNTLLRDWD LWGPLILCVT LALMLQRDSA DSEKDGGPQF
   121  AEVFVIVWFG AVTITLNSKL LGGNISFFQS LCVLGYCILP LTVAMLICRL VLLADPGPVN
   181  FMVRLFVVIV MFAWSIVAST AFLADSQPPN RRALAVYPVF LFYFVISWMI LTFTPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YIPF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 20 nTPM
liver: 20 nTPM
parathyroid gland: 19 nTPM
prostate: 19 nTPM
kidney: 18 nTPM
placenta: 17 nTPM

Single-cell type

syncytiotrophoblasts: 405 nCPM
esophageal apical cells: 216 nCPM
extravillous trophoblasts: 157 nCPM
parietal cells: 129 nCPM
cytotrophoblasts: 129 nCPM
migrating cytotrophoblasts: 126 nCPM

Immune cell

neutrophil: 11 nTPM
basophil: 5.3 nTPM
eosinophil: 4.7 nTPM
intermediate monocyte: 4.7 nTPM
non-classical monocyte: 4.2 nTPM
classical monocyte: 4 nTPM

Brain region

midbrain: 30 nTPM
medulla oblongata: 28 nTPM
hypothalamus: 28 nTPM
thalamus: 28 nTPM
cerebellum: 27 nTPM
choroid plexus: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.9
gnomAD missense Z: 1.21
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YIPF6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YIPF6 as an antibody target. Whether an autoantibody or antibody against YIPF6 could matter depends on whether native YIPF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YIPF6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YIPF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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