Seroatlas · Human Serome Atlas

YIPF1

Protein YIPF1

Also known as: DJ167A19.1, FinGER1, YIPF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y548
Gene: YIPF1
Ensembl: ENSG00000058799
Chromosome: 1
Canonical length: 306 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Golgi apparatus,Plasma membrane

OverviewNCBI Gene

Predicted to enable small GTPase binding activity. Predicted to be involved in vesicle-mediated transport. Located in several cellular components, including Golgi apparatus subcompartment; nucleoplasm; and transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

306 residues, UniProt reviewed canonical sequence.

>Q9Y548|YIPF1
     1  MAAVDDLQFE EFGNAATSLT ANPDATTVNI EDPGETPKHQ PGSPRGSGRE EDDELLGNDD
    61  SDKTELLAGQ KKSSPFWTFE YYQTFFDVDT YQVFDRIKGS LLPIPGKNFV RLYIRSNPDL
   121  YGPFWICATL VFAIAISGNL SNFLIHLGEK TYHYVPEFRK VSIAATIIYA YAWLVPLALW
   181  GFLMWRNSKV MNIVSYSFLE IVCVYGYSLF IYIPTAILWI IPQKAVRWIL VMIALGISGS
   241  LLAMTFWPAV REDNRRVALA TIVTIVLLHM LLSVGCLAYF FDAPEMDHLP TTTATPNQTV
   301  AAAKSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YIPF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 21 nTPM
choroid plexus: 15 nTPM
skeletal muscle: 14 nTPM
liver: 13 nTPM
salivary gland: 11 nTPM
kidney: 11 nTPM

Single-cell type

syncytiotrophoblasts: 168 nCPM
cytotrophoblasts: 101 nCPM
neutrophils: 98 nCPM
late spermatids: 93 nCPM
esophageal apical cells: 92 nCPM
prostatic glandular cells: 83 nCPM

Immune cell

neutrophil: 38 nTPM
T-reg: 24 nTPM
non-classical monocyte: 24 nTPM
eosinophil: 20 nTPM
basophil: 19 nTPM
classical monocyte: 18 nTPM

Brain region

choroid plexus: 8.8 nTPM
medulla oblongata: 8.4 nTPM
pons: 8.4 nTPM
white matter: 7.7 nTPM
hypothalamus: 7.5 nTPM
spinal cord: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: -0.14
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

vesicle-mediated transport

Molecular functions

small GTPase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YIPF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YIPF1 as an antibody target. Whether an autoantibody or antibody against YIPF1 could matter depends on whether native YIPF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YIPF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YIPF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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