Seroatlas · Human Serome Atlas

TVP23B

Golgi apparatus membrane protein TVP23 homolog B

Also known as: CGI-148, FAM18B, FAM18B1, TV23B_HUMAN, YDR084C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYZ1
Gene: TVP23B
Ensembl: ENSG00000171928
Chromosome: 17
Canonical length: 205 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to be involved in protein secretion and vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q9NYZ1|TVP23B
     1  MLQQDSNDDT EDVSLFDAEE ETTNRPRKAK IRHPVASFFH LFFRVSAIIV YLLCGLLSSS
    61  FITCMVTIIL LLSCDFWAVK NVTGRLMVGL RWWNHIDEDG KSHWVFESRK ESSQENKTVS
   121  EAESRIFWLG LIACPVLWVI FAFSALFSFR VKWLAVVIMG VVLQGANLYG YIRCKVRSRK
   181  HLTSMATSYF GKQFLRQNTG DDQTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TVP23B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

esophagus: 52 nTPM
parathyroid gland: 45 nTPM
thyroid gland: 44 nTPM
liver: 41 nTPM
adrenal gland: 41 nTPM
stomach: 38 nTPM

Single-cell type

esophageal apical cells: 178 nCPM
early primary spermatocytes: 72 nCPM
extravillous trophoblasts: 72 nCPM
differentiating spermatogonia: 54 nCPM
epididymal principal cells: 52 nCPM
mucous neck cells: 51 nCPM

Immune cell

basophil: 55 nTPM
eosinophil: 45 nTPM
MAIT T-cell: 41 nTPM
naive CD4 T-cell: 35 nTPM
naive CD8 T-cell: 35 nTPM
memory CD4 T-cell: 33 nTPM

Brain region

choroid plexus: 35 nTPM
hypothalamus: 15 nTPM
spinal cord: 14 nTPM
white matter: 14 nTPM
medulla oblongata: 14 nTPM
midbrain: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.67

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Golgi membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TVP23B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TVP23B as an antibody target. Whether an autoantibody or antibody against TVP23B could matter depends on whether native TVP23B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TVP23B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TVP23B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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