XPOT

Protein identityUniProt · HPA

UniProt accession

O43592

Gene

XPOT

Ensembl

ENSG00000184575

Chromosome

12

Canonical length

962 aa

Protein class

Predicted intracellular proteins, Transporters

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

962 residues, UniProt reviewed canonical sequence.

>O43592|XPOT
     1  MDEQALLGLN PNADSDFRQR ALAYFEQLKI SPDAWQVCAE ALAQRTYSDD HVKFFCFQVL
    61  EHQVKYKYSE LTTVQQQLIR ETLISWLQAQ MLNPQPEKTF IRNKAAQVFA LLFVTEYLTK
   121  WPKFFFDILS VVDLNPRGVD LYLRILMAID SELVDRDVVH TSEEARRNTL IKDTMREQCI
   181  PNLVESWYQI LQNYQFTNSE VTCQCLEVVG AYVSWIDLSL IANDRFINML LGHMSIEVLR
   241  EEACDCLFEV VNKGMDPVDK MKLVESLCQV LQSAGFFSID QEEDVDFLAR FSKLVNGMGQ
   301  SLIVSWSKLI KNGDIKNAQE ALQAIETKVA LMLQLLIHED DDISSNIIGF CYDYLHILKQ
   361  LTVLSDQQKA NVEAIMLAVM KKLTYDEEYN FENEGEDEAM FVEYRKQLKL LLDRLAQVSP
   421  ELLLASVRRV FSSTLQNWQT TRFMEVEVAI RLLYMLAEAL PVSHGAHFSG DVSKASALQD
   481  MMRTLVTSGV SSYQHTSVTL EFFETVVRYE KFFTVEPQHI PCVLMAFLDH RGLRHSSAKV
   541  RSRTAYLFSR FVKSLNKQMN PFIEDILNRI QDLLELSPPE NGHQSLLSSD DQLFIYETAG
   601  VLIVNSEYPA ERKQALMRNL LTPLMEKFKI LLEKLMLAQD EERQASLADC LNHAVGFASR
   661  TSKAFSNKQT VKQCGCSEVY LDCLQTFLPA LSCPLQKDIL RSGVRTFLHR MIICLEEEVL
   721  PFIPSASEHM LKDCEAKDLQ EFIPLINQIT AKFKIQVSPF LQQMFMPLLH AIFEVLLRPA
   781  EENDQSAALE KQMLRRSYFA FLQTVTGSGM SEVIANQGAE NVERVLVTVI QGAVEYPDPI
   841  AQKTCFIILS KLVELWGGKD GPVGFADFVY KHIVPACFLA PLKQTFDLAD AQTVLALSEC
   901  AVTLKTIHLK RGPECVQYLQ QEYLPSLQVA PEIIQEFCQA LQQPDAKVFK NYLKVFFQRA
   961  KP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XPOT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

47 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.28

gnomAD pLI

1

gnomAD missense Z

2.05

DepMap mean gene effect

-0.53

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• intracellular protein transport
• tRNA export from nucleus
• tRNA re-export from nucleus

Molecular functions

• small GTPase binding
• tRNA binding

Cellular components

• cytoplasm
• cytosol
• nuclear matrix
• nuclear pore
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Importin-beta, N-terminal domain
• Armadillo-like helical
• Exportin-1/Importin-beta-like
• Armadillo-type fold
• Importin-beta N-terminal domain
• Exportin 1-like protein
• Exportin-T
• Exportin-T, C-terminal domain
• Exportin-T

KeywordsUniProt

• Acetylation
• Cytoplasm
• Nucleus
• RNA-binding
• Transport
• tRNA-binding

InteractionsUniProt · HPA

Protein binding partners of XPOT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MFSD4A
• RAN