UQCRB

Protein identityUniProt · HPA

UniProt accession

P14927

Gene

UQCRB

Ensembl

ENSG00000156467

Chromosome

8

Canonical length

111 aa

Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

111 residues, UniProt reviewed canonical sequence.

>P14927|UQCRB
     1  MAGKQAVSAS GKWLDGIRKW YYNAAGFNKL GLMRDDTIYE DEDVKEAIRR LPENLYNDRM
    61  FRIKRALDLN LKHQILPKEQ WTKYEEENFY LEPYLKEVIR ERKEREEWAK K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UQCRB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

1,225 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UQCRB.

Disease | AllUniProt

Conditions UQCRB is implicated in, by any mechanism.

• Mitochondrial complex III deficiency, nuclear type 3 (MC3DN3) MIM:615158

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.08

gnomAD pLI

0.02

gnomAD missense Z

0.19

DepMap mean gene effect

-0.39

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• aerobic respiration
• cellular respiration
• mitochondrial electron transport, ubiquinol to cytochrome c
• oxidative phosphorylation

Cellular components

• mitochondrial inner membrane
• mitochondrion
• respiratory chain complex
• respiratory chain complex III

Protein domainsUniProt · Pfam · InterPro

• Cytochrome b-c1 complex subunit 7
• Cytochrome b-c1 complex subunit 7 superfamily
• Ubiquinol-cytochrome C reductase complex 14kD subunit

KeywordsUniProt

• Acetylation
• Electron transport
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Primary mitochondrial disease
• Respiratory chain
• Transport

InteractionsUniProt · HPA

Protein binding partners of UQCRB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CYC1
• MAGEA4