CYC1

Protein identityUniProt · HPA

UniProt accession

P08574

Gene

CYC1

Ensembl

ENSG00000179091

Chromosome

8

Canonical length

325 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins

Subcellular location

Mitochondria,Equatorial segment

OverviewNCBI Gene

This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>P08574|CYC1
     1  MAAAAASLRG VVLGPRGAGL PGARARGLLC SARPGQLPLR TPQAVALSSK SGLSRGRKVM
    61  LSALGMLAAG GAGLAMALHS AVSASDLELH PPSYPWSHRG LLSSLDHTSI RRGFQVYKQV
   121  CASCHSMDFV AYRHLVGVCY TEDEAKELAA EVEVQDGPNE DGEMFMRPGK LFDYFPKPYP
   181  NSEAARAANN GALPPDLSYI VRARHGGEDY VFSLLTGYCE PPTGVSLREG LYFNPYFPGQ
   241  AIAMAPPIYT DVLEFDDGTP ATMSQIAKDV CTFLRWASEP EHDHRKRMGL KMLMMMALLV
   301  PLVYTIKRHK WSVLKSRKLA YRPPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

684 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CYC1.

Disease | AllUniProt

Conditions CYC1 is implicated in, by any mechanism.

• Mitochondrial complex III deficiency, nuclear type 6 (MC3DN6) MIM:615453

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 185 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Mitochondrial complex III deficiency nuclear type 6

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.64

gnomAD pLI

0.14

gnomAD missense Z

0.13

DepMap mean gene effect

-0.43

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular respiration
• mitochondrial electron transport, ubiquinol to cytochrome c
• response to glucagon

Molecular functions

• heme binding
• metal ion binding
• quinol-cytochrome-c reductase activity

Cellular components

• membrane
• mitochondrial inner membrane
• mitochondrion
• nucleus
• respiratory chain complex III

Protein domainsUniProt · Pfam · InterPro

• Cytochrome c-like domain superfamily
• Cytochrome c1
• Cytochrome c1, transmembrane anchor, C-terminal
• Cytochrome C1 family

KeywordsUniProt

• Electron transport
• Heme
• Iron
• Membrane
• Metal-binding
• Mitochondrion
• Mitochondrion inner membrane
• Phosphoprotein
• Primary mitochondrial disease
• Respiratory chain
• Transit peptide
• Translocase
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of CYC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FLVCR2
• UQCRB