Seroatlas · Human Serome Atlas

TXNL4B

Thioredoxin-like protein 4B

Also known as: Dim2, DLP, FLJ20511, TXN4B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NX01
Gene: TXNL4B
Ensembl: ENSG00000140830
Chromosome: 16
Canonical length: 149 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to be involved in mRNA splicing, via spliceosome. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>Q9NX01|TXNL4B
     1  MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSS DLSKMAAIYL
    61  VDVDQTAVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT KFVGSFKTKQ DFIDLIEVIY
   121  RGAMRGKLIV QSPIDPKNIP KYDLLYQDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TXNL4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

ovary: 19 nTPM
liver: 15 nTPM
testis: 15 nTPM
bone marrow: 14 nTPM
thymus: 11 nTPM
lymph node: 11 nTPM

Single-cell type

epicardial cells: 641 nCPM
cardiomyocytes: 491 nCPM
platelets: 325 nCPM
mesothelial cells: 283 nCPM
adipocytes: 62 nCPM
sertoli cells: 51 nCPM

Immune cell

basophil: 25 nTPM
non-classical monocyte: 14 nTPM
neutrophil: 13 nTPM
eosinophil: 12 nTPM
MAIT T-cell: 12 nTPM
naive CD8 T-cell: 11 nTPM

Brain region

white matter: 29 nTPM
pons: 21 nTPM
basal ganglia: 21 nTPM
medulla oblongata: 21 nTPM
cerebellum: 20 nTPM
hypothalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: -0.79
DepMap mean gene effect: -0.89
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

via spliceosome
mRNA splicing

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TXNL4B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CENATAC

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TXNL4B as an antibody target. Whether an autoantibody or antibody against TXNL4B could matter depends on whether native TXNL4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TXNL4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TXNL4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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