Seroatlas · Human Serome Atlas

CENATAC

Centrosomal AT-AC splicing factor

Also known as: CATAC_HUMAN, CCDC84, DLNB14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UT8
Gene: CENATAC
Ensembl: ENSG00000186166
Chromosome: 11
Canonical length: 332 aa
Protein class: Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein thought to contain a coiled coil motif. No function has been determined for the encoded protein. A pseudogene of this gene is located on chromosome 20. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

332 residues, UniProt reviewed canonical sequence.

>Q86UT8|CENATAC
     1  MAPAQRCPLC RQTFFCGRGH VYSRKHQRQL KEALERLLPQ VEAARKAIRA AQVERYVPEH
    61  ERCCWCLCCG CEVREHLSHG NLTVLYGGLL EHLASPEHKK ATNKFWWENK AEVQMKEKFL
   121  VTPQDYARFK KSMVKGLDSY EEKEDKVIKE MAAQIREVEQ SRQEVVRSVL EPQAVPDPEE
   181  GSSAPRSWKG MNSQVASSLQ QPSNLDLPPA PELDWMETGP SLTFIGHQDI PGVGNIHSGA
   241  TPPWMIQDEE YIAGNQEIGP SYEEFLKEKE KQKLKKLPPD RVGANFDHSS RTSAGWLPSF
   301  GRVWNNGRRW QSRHQFKTEA AAMKKQSHTE KS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CENATAC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

spleen: 21 nTPM
cerebellum: 21 nTPM
liver: 19 nTPM
choroid plexus: 16 nTPM
prostate: 16 nTPM
pituitary gland: 15 nTPM

Single-cell type

choroid plexus epithelial cells: 203 nCPM
distal convoluted tubule cells: 92 nCPM
renal connecting tubule cells: 85 nCPM
podocytes: 71 nCPM
brain inhibitory neurons: 70 nCPM
proximal tubule cells: 68 nCPM

Immune cell

T-reg: 5.8 nTPM
naive B-cell: 4.2 nTPM
memory B-cell: 4.1 nTPM
NK-cell: 3.8 nTPM
memory CD4 T-cell: 3.6 nTPM
MAIT T-cell: 3.4 nTPM

Brain region

choroid plexus: 5.6 nTPM
cerebellum: 2.6 nTPM
white matter: 2.4 nTPM
cerebral cortex: 2.2 nTPM
thalamus: 2.2 nTPM
hypothalamus: 2.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CENATAC.

Disease | AllUniProt

Conditions CENATAC is implicated in, by any mechanism.

Mosaic variegated aneuploidy syndrome 4 (MVA4) MIM:620153

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 86 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Mosaic variegated aneuploidy syndrome 4

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
DepMap mean gene effect: -1.19
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

centrosome

Protein domainsUniProt · Pfam · InterPro

CCDC84-like
Coiled coil protein 84

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CENATAC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CENATAC as an antibody target. Whether an autoantibody or antibody against CENATAC could matter depends on whether native CENATAC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CENATAC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CENATAC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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