Seroatlas · Human Serome Atlas

TSSK2

Testis-specific serine/threonine-protein kinase 2

Also known as: FLJ38613, SPOGA2, STK22B, TSSK2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PF2
Gene: TSSK2
Ensembl: ENSG00000206203
Chromosome: 22
Canonical length: 358 aa
Protein class: Enzymes, Predicted membrane proteins

OverviewNCBI Gene

TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>Q96PF2|TSSK2
     1  MDDATVLRKK GYIVGINLGK GSYAKVKSAY SERLKFNVAV KIIDRKKTPT DFVERFLPRE
    61  MDILATVNHG SIIKTYEIFE TSDGRIYIIM ELGVQGDLLE FIKCQGALHE DVARKMFRQL
   121  SSAVKYCHDL DIVHRDLKCE NLLLDKDFNI KLSDFGFSKR CLRDSNGRII LSKTFCGSAA
   181  YAAPEVLQSI PYQPKVYDIW SLGVILYIMV CGSMPYDDSD IRKMLRIQKE HRVDFPRSKN
   241  LTCECKDLIY RMLQPDVSQR LHIDEILSHS WLQPPKPKAT SSASFKREGE GKYRAECKLD
   301  TKTGLRPDHR PDHKLGAKTQ HRLLVVPENE NRMEDRLAET SRAKDHHISG AEVGKAST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSSK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 181 nTPM

Expression across tissuesHPA

Tissue

testis: 181 nTPM
pancreas: 0.5 nTPM
appendix: 0.2 nTPM
breast: 0.1 nTPM
cerebellum: 0.1 nTPM
heart muscle: 0.1 nTPM

Single-cell type

late spermatids: 5,701 nCPM
early spermatids: 1,920 nCPM
late primary spermatocytes: 419 nCPM
sertoli cells: 15 nCPM
leydig cells: 9.9 nCPM
early primary spermatocytes: 5.7 nCPM

Immune cell

eosinophil: 0.1 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 0.7 nTPM
cerebellum: 0.6 nTPM
medulla oblongata: 0.6 nTPM
cerebral cortex: 0.5 nTPM
hippocampal formation: 0.5 nTPM
pons: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 0.81
DepMap mean gene effect: -0.11
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSSK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HSP90
TSSK1B
TSKS

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSSK2 as an antibody target. Whether an autoantibody or antibody against TSSK2 could matter depends on whether native TSSK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSSK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSSK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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