Seroatlas · Human Serome Atlas

TSKS

Testis-specific serine kinase substrate

Also known as: PPP1R161, TSKS_HUMAN, TSSKS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJT2
Gene: TSKS
Ensembl: ENSG00000126467
Chromosome: 19
Canonical length: 592 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

592 residues, UniProt reviewed canonical sequence.

>Q9UJT2|TSKS
     1  MASVVVKTIW QSKEIHEAGD TPTGVESCSQ LVPEAPRRVT SRAKGIPKKK KAVSFHGVEP
    61  QMSHQPMHWC LNLKRSSACT NVSLLNLAAM EPTDSTGTDS TVEDLSGQLT LAGPPASPTL
   121  PWDPDDADIT EILSGVNSGL VRAKDSITSL KEKTNRVNQH VQSLQSECSV LSENLERRRQ
   181  EAEELEGYCI QLKENCWKVT RSVEDAEIKT NVLKQNSALL EEKLRYLQQQ LQDETPRRQE
   241  AELQEPEEKQ EPEEKQEPEE KQKPEAGLSW NSLGPAATSQ GCPGPPGSPD KPSRPHGLVP
   301  AGWGMGPRAG EGPYVSEQEL QKLFTGIEEL RREVSSLTAR WHQEEGAVQE ALRLLGGLGG
   361  RVDGFLGQWE RAQREQAQTA RDLQELRGRA DELCTMVERS AVSVASLRSE LEGLGPLKPI
   421  LEEFGRQFQN SRRGPDLSMN LDRSHQGNCA RCASQGSQLS TESLQQLLDR ALTSLVDEVK
   481  QRGLTPACPS CQRLHKKILE LERQALAKHV RAEALSSTLR LAQDEALRAK NLLLTDKMKP
   541  EEKMATLDHL HLKMCSLHDH LSNLPLEGST GTMGGGSSAG TPPKQGGSAP EQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSKS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 116 nTPM

Expression across tissuesHPA

Tissue

testis: 116 nTPM
skin: 1.7 nTPM
heart muscle: 1.5 nTPM
adipose tissue: 1.1 nTPM
blood vessel: 0.9 nTPM
breast: 0.9 nTPM

Single-cell type

late spermatids: 1,393 nCPM
early spermatids: 1,128 nCPM
late primary spermatocytes: 295 nCPM
migrating cytotrophoblasts: 30 nCPM
thymic myoid cells: 18 nCPM
fibro-adipogenic progenitors: 17 nCPM

Immune cell

non-classical monocyte: 1 nTPM
memory CD4 T-cell: 0.8 nTPM
myeloid DC: 0.8 nTPM
plasmacytoid DC: 0.7 nTPM
T-reg: 0.7 nTPM
classical monocyte: 0.5 nTPM

Brain region

cerebellum: 1.6 nTPM
white matter: 0.5 nTPM
basal ganglia: 0.4 nTPM
cerebral cortex: 0.4 nTPM
hypothalamus: 0.4 nTPM
thalamus: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 1
gnomAD missense Z: 0.28
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein kinase binding

Cellular components

centriole

Protein domainsUniProt · Pfam · InterPro

Testis-specific serine kinase substrate
Testis-specific serine kinase substrate

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSKS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TSSK2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSKS as an antibody target. Whether an autoantibody or antibody against TSKS could matter depends on whether native TSKS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSKS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSKS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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