Seroatlas · Human Serome Atlas

TSSK1B

Testis-specific serine/threonine-protein kinase 1

Also known as: FKSG81, SPOGA4, STK22D, TSSK1, TSSK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXA7
Gene: TSSK1B
Ensembl: ENSG00000212122
Chromosome: 5
Canonical length: 367 aa
Protein class: Enzymes, Predicted membrane proteins
Subcellular location: Nuclear bodies,Centrosome,Basal body,Perinuclear theca,Principal piece,End piece,Annulus

OverviewNCBI Gene

TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

367 residues, UniProt reviewed canonical sequence.

>Q9BXA7|TSSK1B
     1  MDDAAVLKRR GYLLGINLGE GSYAKVKSAY SERLKFNVAI KIIDRKKAPA DFLEKFLPRE
    61  IEILAMLNHC SIIKTYEIFE TSHGKVYIVM ELAVQGDLLE LIKTRGALHE DEARKKFHQL
   121  SLAIKYCHDL DVVHRDLKCD NLLLDKDFNI KLSDFSFSKR CLRDDSGRMA LSKTFCGSPA
   181  YAAPEVLQGI PYQPKVYDIW SLGVILYIMV CGSMPYDDSN IKKMLRIQKE HRVNFPRSKH
   241  LTGECKDLIY HMLQPDVNRR LHIDEILSHC WMQPKARGSP SVAINKEGES SRGTEPLWTP
   301  EPGSDKKSAT KLEPEGEAQP QAQPETKPEG TAMQMSRQSE ILGFPSKPST METEEGPPQQ
   361  PPETRAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSSK1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

testis: 52 nTPM
skin: 0.2 nTPM
prostate: 0.1 nTPM
retina: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late spermatids: 9.6 nCPM
early spermatids: 2.9 nCPM
late primary spermatocytes: 1.1 nCPM
peritubular myoid cells: 0.3 nCPM
leydig cells: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 0.6 nTPM
medulla oblongata: 0.5 nTPM
cerebellum: 0.4 nTPM
cerebral cortex: 0.4 nTPM
hypothalamus: 0.4 nTPM
pons: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0
gnomAD missense Z: -0.34
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSSK1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSSK1B as an antibody target. Whether an autoantibody or antibody against TSSK1B could matter depends on whether native TSSK1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSSK1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TSSK1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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