FAM229B
Protein FAM229B
Also known as: C6orf225, DKFZp586F0922, F229B_HUMAN, LOC619208
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q4G0N7
- Gene
- FAM229B
- Ensembl
- ENSG00000203778
- Chromosome
- 6
- Canonical length
- 80 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli,Golgi apparatus
OverviewNCBI Gene
No narrative summary is available for FAM229B in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
80 residues, UniProt reviewed canonical sequence.
>Q4G0N7|FAM229B
1 MPFQFGTQPR RFPVEGGDSS IELEPGLSSS AACNGKEMSP TRQLRRCPGS HCLTITDVPV
61 TVYATTRKPP AQSSKEMHPKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM229B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 428 nTPM
Expression across tissuesHPA
Tissue
- testis: 428 nTPM
- spinal cord: 101 nTPM
- choroid plexus: 99 nTPM
- midbrain: 89 nTPM
- amygdala: 75 nTPM
- basal ganglia: 71 nTPM
Single-cell type
- late spermatids: 10,748 nCPM
- early spermatids: 3,604 nCPM
- late primary spermatocytes: 2,623 nCPM
- respiratory ciliated cells: 476 nCPM
- epididymal efferent duct ciliated cells: 387 nCPM
- fallopian tube ciliated cells: 385 nCPM
Immune cell
- naive CD4 T-cell: 5.6 nTPM
- naive CD8 T-cell: 5.1 nTPM
- NK-cell: 4.6 nTPM
- MAIT T-cell: 3.9 nTPM
- gdT-cell: 3 nTPM
- memory CD4 T-cell: 2.6 nTPM
Brain region
- white matter: 71 nTPM
- spinal cord: 66 nTPM
- medulla oblongata: 63 nTPM
- midbrain: 60 nTPM
- hypothalamus: 57 nTPM
- basal ganglia: 56 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.12
- gnomAD pLI
- 0.57
- gnomAD missense Z
- 0.18
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
InteractionsUniProt · HPA
Protein binding partners of FAM229B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM229B as an antibody target. Whether an autoantibody or antibody against FAM229B could matter depends on whether native FAM229B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM229B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM229B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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