Seroatlas · Human Serome Atlas

TRMT6

tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

Also known as: CGI-09, GCD10, Gcd10p, MGC5029, TRM6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJA5
Gene: TRMT6
Ensembl: ENSG00000089195
Chromosome: 20
Canonical length: 497 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cell Junctions

OverviewNCBI Gene

This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

497 residues, UniProt reviewed canonical sequence.

>Q9UJA5|TRMT6
     1  MEGSGEQPGP QPQHPGDHRI RDGDFVVLKR EDVFKAVQVQ RRKKVTFEKQ WFYLDNVIGH
    61  SYGTAFEVTS GGSLQPKKKR EEPTAETKEA GTDNRNIVDD GKSQKLTQDD IKALKDKGIK
   121  GEEIVQQLIE NSTTFRDKTE FAQDKYIKKK KKKYEAIITV VKPSTRILSI MYYAREPGKI
   181  NHMRYDTLAQ MLTLGNIRAG NKMIVMETCA GLVLGAMMER MGGFGSIIQL YPGGGPVRAA
   241  TACFGFPKSF LSGLYEFPLN KVDSLLHGTF SAKMLSSEPK DSALVEESNG TLEEKQASEQ
   301  ENEDSMAEAP ESNHPEDQET METISQDPEH KGPKERGSKK DYIQEKQRRQ EEQRKRHLEA
   361  AALLSERNAD GLIVASRFHP TPLLLSLLDF VAPSRPFVVY CQYKEPLLEC YTKLRERGGV
   421  INLRLSETWL RNYQVLPDRS HPKLLMSGGG GYLLSGFTVA MDNLKADTSL KSNASTLESH
   481  ETEEPAAKKR KCPESDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRMT6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 17 nTPM
bone marrow: 13 nTPM
testis: 11 nTPM
urinary bladder: 10 nTPM
seminal vesicle: 9.4 nTPM
cerebellum: 8.9 nTPM

Single-cell type

oocytes: 147 nCPM
differentiating spermatogonia: 115 nCPM
early primary spermatocytes: 103 nCPM
monocytes: 59 nCPM
esophageal basal cells: 54 nCPM
undifferentiated spermatogonia: 47 nCPM

Immune cell

myeloid DC: 18 nTPM
NK-cell: 16 nTPM
T-reg: 13 nTPM
memory CD8 T-cell: 12 nTPM
naive CD8 T-cell: 11 nTPM
MAIT T-cell: 11 nTPM

Brain region

cerebellum: 7.2 nTPM
pons: 7.1 nTPM
cerebral cortex: 6.8 nTPM
hippocampal formation: 6.2 nTPM
medulla oblongata: 6 nTPM
hypothalamus: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 1.03
DepMap mean gene effect: -0.39
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
Gcd10p family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRMT6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRMT6 as an antibody target. Whether an autoantibody or antibody against TRMT6 could matter depends on whether native TRMT6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRMT6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRMT6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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