Seroatlas · Human Serome Atlas

TRMT61A

tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

Also known as: C14orf172, FLJ40452, GCD14, Gcd14p, hTRM61, TRM61_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96FX7
Gene
TRMT61A
Ensembl
ENSG00000166166
Chromosome
14
Canonical length
289 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Enables mRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA processing. Part of tRNA (m1A) methyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

289 residues, UniProt reviewed canonical sequence.

>Q96FX7|TRMT61A
     1  MSFVAYEELI KEGDTAILSL GHGAMVAVRV QRGAQTQTRH GVLRHSVDLI GRPFGSKVTC
    61  GRGGWVYVLH PTPELWTLNL PHRTQILYST DIALITMMLE LRPGSVVCES GTGSGSVSHA
   121  IIRTIAPTGH LHTVEFHQQR AEKAREEFQE HRVGRWVTVR TQDVCRSGFG VSHVADAVFL
   181  DIPSPWEAVG HAWDALKVEG GRFCSFSPCI EQVQRTCQAL AARGFSELST LEVLPQVYNV
   241  RTVSLPPPDL GTGTDGPAGS DTSPFRSGTP MKEAVGHTGY LTFATKTPG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRMT61A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • colon: 24 nTPM
  • urinary bladder: 19 nTPM
  • basal ganglia: 18 nTPM
  • endometrium: 18 nTPM
  • fallopian tube: 18 nTPM
  • prostate: 17 nTPM

Single-cell type

  • decidual stromal cells: 35 nCPM
  • esophageal basal cells: 31 nCPM
  • alveolar cells type 1: 24 nCPM
  • late spermatids: 24 nCPM
  • suprabasal keratinocytes: 23 nCPM
  • basal keratinocytes: 23 nCPM

Immune cell

  • non-classical monocyte: 11 nTPM
  • intermediate monocyte: 5.4 nTPM
  • myeloid DC: 3.3 nTPM
  • memory CD8 T-cell: 2.8 nTPM
  • NK-cell: 2.7 nTPM
  • gdT-cell: 2.6 nTPM

Brain region

  • basal ganglia: 21 nTPM
  • white matter: 19 nTPM
  • cerebral cortex: 18 nTPM
  • medulla oblongata: 18 nTPM
  • thalamus: 17 nTPM
  • midbrain: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRMT61A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 47 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0.02
gnomAD missense Z
1.28
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRMT61A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRMT61A as an antibody target. Whether an autoantibody or antibody against TRMT61A could matter depends on whether native TRMT61A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRMT61A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRMT61A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRMT61A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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