Seroatlas · Human Serome Atlas

TRMT1L

tRNA (guanine(27)-N(2))-dimethyltransferase

Also known as: C1orf25, TRM1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z2T5
Gene: TRMT1L
Ensembl: ENSG00000121486
Chromosome: 1
Canonical length: 733 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may also be involved in modulating postnatal neuronal functions. Alternatively spliced transcripts have been identified for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

733 residues, UniProt reviewed canonical sequence.

>Q7Z2T5|TRMT1L
     1  MENMAEEELL PLEKEEVEVA QVQVPTPARD SAGVPAPAPD SALDSAPTPA SAPAPAPALA
    61  QAPALSPSLA SAPEEAKSKR HISIQRQLAD LENLAFVTDG NFDSASSLNS DNLDAGNRQA
   121  CPLCPKEKFR ACNSHKLRRH LQNLHWKVSV EFEGYRMCIC HLPCRPVKPN IIGEQITSKM
   181  GAHYHCIICS ATITRRTDML GHVRRHMNKG ETKSSYIAAS TAKPPKEILK EADTDVQVCP
   241  NYSIPQKTDS YFNPKMKLNR QLIFCTLAAL AEERKPLECL DAFGATGIMG LQWAKHLGNA
   301  VKVTINDLNE NSVTLIQENC HLNKLKVVVD SKEKEKSDDI LEEGEKNLGN IKVTKMDANV
   361  LMHLRSFDFI HLDPFGTSVN YLDSAFRNIR NLGIVSVTST DISSLYAKAQ HVARRHYGCN
   421  IVRTEYYKEL AARIVVAAVA RAAARCNKGI EVLFAVALEH FVLVVVRVLR GPTSADETAK
   481  KIQYLIHCQW CEERIFQKDG NMVEENPYRQ LPCNCHGSMP GKTAIELGPL WSSSLFNTGF
   541  LKRMLFESLH HGLDDIQTLI KTLIFESECT PQSQFSIHAS SNVNKQEENG VFIKTTDDTT
   601  TDNYIAQGKR KSNEMITNLG KKQKTDVSTE HPPFYYNIHR HSIKGMNMPK LKKFLCYLSQ
   661  AGFRVSRTHF DPMGVRTDAP LMQFKSILLK YSTPTYTGGQ SESHVQSASE DTVTERVEMS
   721  VNDKAEASGC RRW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRMT1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

testis: 26 nTPM
skeletal muscle: 20 nTPM
tongue: 17 nTPM
liver: 14 nTPM
kidney: 12 nTPM
parathyroid gland: 11 nTPM

Single-cell type

late primary spermatocytes: 167 nCPM
early primary spermatocytes: 84 nCPM
oocytes: 78 nCPM
respiratory ciliated cells: 74 nCPM
sertoli cells: 72 nCPM
neutrophil progenitors: 59 nCPM

Immune cell

basophil: 24 nTPM
eosinophil: 22 nTPM
non-classical monocyte: 19 nTPM
naive B-cell: 18 nTPM
intermediate monocyte: 15 nTPM
T-reg: 14 nTPM

Brain region

white matter: 23 nTPM
cerebellum: 18 nTPM
choroid plexus: 17 nTPM
spinal cord: 17 nTPM
medulla oblongata: 16 nTPM
basal ganglia: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.8
gnomAD missense Z: 1.86
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

tRNA N2-guanine methylation

Molecular functions

RNA binding
tRNA binding
zinc ion binding
tRNA (guanine(27)-N2)-dimethyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRMT1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRMT1L as an antibody target. Whether an autoantibody or antibody against TRMT1L could matter depends on whether native TRMT1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRMT1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRMT1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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