Seroatlas · Human Serome Atlas

TPD52L1

Tumor protein D53

Also known as: D53, hD53, TPD53, TPD53_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16890
Gene: TPD52L1
Ensembl: ENSG00000111907
Chromosome: 6
Canonical length: 204 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cell Junctions,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>Q16890|TPD52L1
     1  MEAQAQGLLE TEPLQGTDED AVASADFSSM LSEEEKEELK AELVQLEDEI TTLRQVLSAK
    61  ERHLVEIKQK LGMNLMNELK QNFSKSWHDM QTTTAYKKTH ETLSHAGQKA TAAFSNVGTA
   121  ISKKFGDMSY SIRHSISMPA MRNSPTFKSF EERVETTVTS LKTKVGGTNP NGGSFEEVLS
   181  STAHASAQSL AGGSRRTKEE ELQC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPD52L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 281 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 281 nTPM
adrenal gland: 249 nTPM
choroid plexus: 212 nTPM
basal ganglia: 165 nTPM
esophagus: 144 nTPM
tongue: 118 nTPM

Single-cell type

esophageal apical cells: 1,258 nCPM
esophageal suprabasal cells: 883 nCPM
myonuclei: 858 nCPM
choroid plexus epithelial cells: 741 nCPM
salivary acinar cells: 695 nCPM
adrenal cortex cells: 645 nCPM

Immune cell

neutrophil: 2.7 nTPM
NK-cell: 2.6 nTPM
basophil: 1.5 nTPM
naive CD4 T-cell: 0.7 nTPM
memory CD4 T-cell: 0.6 nTPM
naive CD8 T-cell: 0.5 nTPM

Brain region

choroid plexus: 86 nTPM
basal ganglia: 71 nTPM
amygdala: 44 nTPM
hypothalamus: 41 nTPM
medulla oblongata: 40 nTPM
cerebral cortex: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 1.11
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TPD52L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TPD52

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPD52L1 as an antibody target. Whether an autoantibody or antibody against TPD52L1 could matter depends on whether native TPD52L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPD52L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPD52L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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