Seroatlas · Human Serome Atlas

TPRKB

EKC/KEOPS complex subunit TPRKB

Also known as: CGI-121, CGI121, TPRKB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y3C4
Gene
TPRKB
Ensembl
ENSG00000144034
Chromosome
2
Canonical length
175 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables protein kinase binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytosol and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 5. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

175 residues, UniProt reviewed canonical sequence.

>Q9Y3C4|TPRKB
     1  MQLTHQLDLF PECRVTLLLF KDVKNAGDLR RKAMEGTIDG SLINPTVIVD PFQILVAANK
    61  AVHLYKLGKM KTRTLSTEII FNLSPNNNIS EALKKFGISA NDTSILIVYI EEGEKQINQE
   121  YLISQVEGHQ VSLKNLPEIM NITEVKKIYK LSSQEESIGT LLDAIICRMS TKDVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPRKB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 67 nTPM
  • bone marrow: 66 nTPM
  • fallopian tube: 52 nTPM
  • testis: 48 nTPM
  • tongue: 48 nTPM
  • ovary: 45 nTPM

Single-cell type

  • late primary spermatocytes: 377 nCPM
  • megakaryocytes: 216 nCPM
  • epididymal efferent duct absorptive cells: 205 nCPM
  • esophageal basal cells: 184 nCPM
  • early primary spermatocytes: 181 nCPM
  • esophageal apical cells: 168 nCPM

Immune cell

  • basophil: 33 nTPM
  • plasmacytoid DC: 30 nTPM
  • eosinophil: 29 nTPM
  • intermediate monocyte: 28 nTPM
  • naive CD4 T-cell: 27 nTPM
  • MAIT T-cell: 26 nTPM

Brain region

  • cerebellum: 11 nTPM
  • white matter: 8.4 nTPM
  • cerebral cortex: 8.1 nTPM
  • medulla oblongata: 7.8 nTPM
  • pons: 7.5 nTPM
  • spinal cord: 7.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TPRKB.

Disease | AllUniProt

Conditions TPRKB is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 69 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Galloway-Mowat syndrome 5

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.31
gnomAD pLI
0.01
gnomAD missense Z
0.1
DepMap mean gene effect
-0.59
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • CGI121/TPRKB
  • CGI121/TPRKB superfamily
  • Kinase binding protein CGI-121

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TPRKB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPRKB as an antibody target. Whether an autoantibody or antibody against TPRKB could matter depends on whether native TPRKB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPRKB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPRKB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TPRKB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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