Seroatlas · Human Serome Atlas

TNK1

Non-receptor tyrosine-protein kinase TNK1

Also known as: KOS1, TNK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13470
Gene: TNK1
Ensembl: ENSG00000174292
Chromosome: 17
Canonical length: 666 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cell Junctions

OverviewNCBI Gene

The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

666 residues, UniProt reviewed canonical sequence.

>Q13470|TNK1
     1  MLPEAGSLWL LKLLRDIQLA QFYWPILEEL NVTRPEHFDF VKPEDLDGIG MGRPAQRRLS
    61  EALKRLRSGP KSKNWVYKIL GGFAPEHKEP TLPSDSPRHL PEPEGGLKCL IPEGAVCRGE
   121  LLGSGCFGVV HRGLWTLPSG KSVPVAVKSL RVGPEGPMGT ELGDFLREVS VMMNLEHPHV
   181  LRLHGLVLGQ PLQMVMELAP LGSLHARLTA PAPTPPLLVA LLCLFLRQLA GAMAYLGARG
   241  LVHRDLATRN LLLASPRTIK VADFGLVRPL GGARGRYVMG GPRPIPYAWC APESLRHGAF
   301  SSASDVWMFG VTLWEMFSGG EEPWAGVPPY LILQRLEDRA RLPRPPLCSR ALYSLALRCW
   361  APHPADRPSF SHLEGLLQEA GPSEACCVRD VTEPGALRME TGDPITVIEG SSSFHSPDST
   421  IWKGQNGRTF KVGSFPASAV TLADAGGLPA TRPVHRGTPA RGDQHPGSID GDRKKANLWD
   481  APPARGQRRN MPLERMKGIS RSLESVLSLG PRPTGGGSSP PEIRQARAVP QGPPGLPPRP
   541  PLSSSSPQPS QPSRERLPWP KRKPPHNHPM GMPGARKAAA LSGGLLSDPE LQRKIMEVEL
   601  SVHGVTHQEC QTALGATGGD VVSAIRNLKV DQLFHLSSRS RADCWRILEH YQWDLSAASR
   661  YVLARP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

stomach: 10 nTPM
skin: 8.9 nTPM
duodenum: 7.5 nTPM
small intestine: 6.7 nTPM
parathyroid gland: 6.2 nTPM
pancreas: 6.1 nTPM

Single-cell type

papillary tip epithelial cells: 3.1 nCPM
renal collecting duct principal cells: 3 nCPM
brain inhibitory neurons: 2.9 nCPM
loop of henle epithelial cells: 2.9 nCPM
brain excitatory neurons: 2.4 nCPM
distal convoluted tubule cells: 2.1 nCPM

Immune cell

naive CD8 T-cell: 2.6 nTPM
naive CD4 T-cell: 2.3 nTPM
MAIT T-cell: 1.3 nTPM
memory CD4 T-cell: 1.2 nTPM
memory B-cell: 1 nTPM
naive B-cell: 1 nTPM

Brain region

cerebellum: 11 nTPM
choroid plexus: 6.1 nTPM
basal ganglia: 3.8 nTPM
cerebral cortex: 3.3 nTPM
hypothalamus: 3.3 nTPM
amygdala: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 1
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNK1 as an antibody target. Whether an autoantibody or antibody against TNK1 could matter depends on whether native TNK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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