TNFSF13B

Protein identityUniProt · HPA

UniProt accession

Q9Y275

Gene

TNFSF13B

Ensembl

ENSG00000102524

Chromosome

13

Canonical length

285 aa

Protein class

Cancer-related genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Subcellular location

Vesicles,Plasma membrane,Focal adhesion sites

Secretome location

Secreted to blood

Quaternary structure

Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

285 residues, UniProt reviewed canonical sequence.

>Q9Y275|TNFSF13B
     1  MDDSTEREQS RLTSCLKKRE EMKLKECVSI LPRKESPSVR SSKDGKLLAA TLLLALLSCC
    61  LTVVSFYQVA ALQGDLASLR AELQGHHAEK LPAGAGAPKA GLEEAPAVTA GLKIFEPPAP
   121  GEGNSSQNSR NKRAVQGPEE TVTQDCLQLI ADSETPTIQK GSYTFVPWLL SFKRGSALEE
   181  KENKILVKET GYFFIYGQVL YTDKTYAMGH LIQRKKVHVF GDELSLVTLF RCIQNMPETL
   241  PNNSCYSAGI AKLEEGDELQ LAIPRENAQI SLDGDVTFFG ALKLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFSF13B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

24 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.24

gnomAD pLI

0.98

gnomAD missense Z

2.14

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• B cell costimulation
• B cell homeostasis
• B cell proliferation
• germinal center formation
• immune response
• lymphocyte homeostasis
• positive regulation of B cell proliferation
• positive regulation of germinal center formation
• positive regulation of T cell proliferation
• signal transduction
• skin development
• T cell costimulation
• T cell proliferation
• transitional one stage B cell differentiation
• tumor necrosis factor-mediated signaling pathway

Molecular functions

• cytokine activity
• signaling receptor binding
• tumor necrosis factor receptor binding

Cellular components

• cytoplasm
• extracellular region
• extracellular space
• focal adhesion
• membrane
• perinuclear region of cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Tumour necrosis factor domain
• Tumour necrosis factor-like domain superfamily
• Tumor Necrosis Factor Ligand Superfamily
• TNF(Tumour Necrosis Factor) family

KeywordsUniProt

• Cell membrane
• Cleavage on pair of basic residues
• Cytokine
• Disulfide bond
• Glycoprotein
• Immunity
• Membrane
• Secreted
• Signal-anchor
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of TNFSF13B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CSE1L
• KPNB1
• TNFRSF13B