TNFRSF13B

Protein identityUniProt · HPA

UniProt accession

O14836

Gene

TNFRSF13B

Ensembl

ENSG00000240505

Chromosome

17

Canonical length

293 aa

Protein class

CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>O14836|TNFRSF13B
     1  MSGLGRSRRG GRSRVDQEER FPQGLWTGVA MRSCPEEQYW DPLLGTCMSC KTICNHQSQR
    61  TCAAFCRSLS CRKEQGKFYD HLLRDCISCA SICGQHPKQC AYFCENKLRS PVNLPPELRR
   121  QRSGEVENNS DNSGRYQGLE HRGSEASPAL PGLKLSADQV ALVYSTLGLC LCAVLCCFLV
   181  AVACFLKKRG DPCSCQPRSR PRQSPAKSSQ DHAMEAGSPV STSPEPVETC SFCFPECRAP
   241  TQESAVTPGT PDPTCAGRWG CHTRTTVLQP CPHIPDSGLG IVCVPAQEGG PGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF13B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.62

Highest tissue expression

59 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TNFRSF13B.

Disease | AllUniProt

Conditions TNFRSF13B is implicated in, by any mechanism.

• Immunodeficiency, common variable, 2 (CVID2) MIM:240500
• Immunoglobulin A deficiency 2 (IGAD2) MIM:609529

Disease | GeneticClinVar

34 pathogenic / likely-pathogenic of 380 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Immunodeficiency, common variable, 2
• Immunoglobulin A deficiency 2
• TNFRSF13B-related disorder
• Immunodeficiency, common variable, 1
• Common variable immunodeficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.96

gnomAD pLI

0

gnomAD missense Z

-1.2

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adaptive immune response
• B cell homeostasis
• cell surface receptor signaling pathway
• hematopoietic progenitor cell differentiation
• negative regulation of B cell proliferation

Molecular functions

• signaling receptor activity

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• TACI, cysteine-rich domain
• Tumour necrosis factor receptor 13B
• TACI, cysteine-rich domain

KeywordsUniProt

• Adaptive immunity
• Disulfide bond
• Glycoprotein
• Immunity
• Membrane
• Receptor
• Repeat
• Signal-anchor
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of TNFRSF13B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TNFSF13B