Seroatlas · Human Serome Atlas

TMIGD2

Transmembrane and immunoglobulin domain-containing protein 2

Also known as: CD28H, IGPR-1, MGC23244, TMIG2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BF3
Gene: TMIGD2
Ensembl: ENSG00000167664
Chromosome: 19
Canonical length: 282 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables coreceptor activity. Involved in positive regulation of T cell activation; positive regulation of angiogenesis; and positive regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

282 residues, UniProt reviewed canonical sequence.

>Q96BF3|TMIGD2
     1  MGSPGMVLGL LVQIWALQEA SSLSVQQGPN LLQVRQGSQA TLVCQVDQAT AWERLRVKWT
    61  KDGAILCQPY ITNGSLSLGV CGPQGRLSWQ APSHLTLQLD PVSLNHSGAY VCWAAVEIPE
   121  LEEAEGNITR LFVDPDDPTQ NRNRIASFPG FLFVLLGVGS MGVAAIVWGA WFWGRRSCQQ
   181  RDSGNSPGNA FYSNVLYRPR GAPKKSEDCS GEGKDQRGQS IYSTSFPQPA PRQPHLASRP
   241  CPSPRPCPSP RPGHPVSMVR VSPRPSPTQQ PRPKGFPKVG EE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMIGD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

thymus: 33 nTPM
spleen: 6.2 nTPM
lymph node: 5.9 nTPM
bone marrow: 4.3 nTPM
appendix: 3.9 nTPM
small intestine: 3.9 nTPM

Single-cell type

nk-cells: 147 nCPM
innate lymphoid cells: 140 nCPM
pdcs: 72 nCPM
t-cells: 29 nCPM
thymocytes: 26 nCPM
microglia: 18 nCPM

Immune cell

MAIT T-cell: 114 nTPM
plasmacytoid DC: 109 nTPM
NK-cell: 89 nTPM
naive CD4 T-cell: 82 nTPM
naive CD8 T-cell: 43 nTPM
total PBMC: 23 nTPM

Brain region

medulla oblongata: 4.1 nTPM
hypothalamus: 4 nTPM
cerebral cortex: 3.8 nTPM
thalamus: 3.8 nTPM
pons: 3.6 nTPM
midbrain: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: 0.1
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

coreceptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMIGD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMIGD2 as an antibody target. Whether an autoantibody or antibody against TMIGD2 could matter depends on whether native TMIGD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMIGD2 is annotated at the cell surface, where native TMIGD2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMIGD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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