Seroatlas · Human Serome Atlas

TMEM30B

Cell cycle control protein 50B

Also known as: CC50B_HUMAN, CDC50B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3MIR4
Gene: TMEM30B
Ensembl: ENSG00000182107
Chromosome: 14
Canonical length: 351 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables aminophospholipid flippase activity. Involved in aminophospholipid transport and positive regulation of protein exit from endoplasmic reticulum. Located in plasma membrane. Part of phospholipid-translocating ATPase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>Q3MIR4|TMEM30B
     1  MTWSATARGA HQPDNTAFTQ QRLPAWQPLL SASIALPLFF CAGLAFIGLG LGLYYSSNGI
    61  KELEYDYTGD PGTGNCSVCA AAGQGRALPP PCSCAWYFSL PELFQGPVYL YYELTNFYQN
   121  NRRYGVSRDD AQLSGLPSAL RHPVNECAPY QRSAAGLPIA PCGAIANSLF NDSFSLWHQR
   181  QPGGPYVEVP LDRSGIAWWT DYHVKFRNPP LVNGSLALAF QGTAPPPNWR RPVYELSPDP
   241  NNTGFINQDF VVWMRTAALP TFRKLYARIR QGNYSAGLPR GAYRVNITYN YPVRAFGGHK
   301  LLIFSSISWM GGKNPFLGIA YLVVGSLCIL TGFVMLVVYI RYQDQDDDDE E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM30B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 56 nTPM
thyroid gland: 47 nTPM
duodenum: 41 nTPM
stomach: 40 nTPM
pancreas: 34 nTPM
small intestine: 32 nTPM

Single-cell type

parietal cells: 133 nCPM
esophageal apical cells: 124 nCPM
urothelial cells: 112 nCPM
foveolar cells: 97 nCPM
prostatic hillock cells: 90 nCPM
gastric chief cells: 85 nCPM

Immune cell

naive CD4 T-cell: 0.7 nTPM
naive CD8 T-cell: 0.5 nTPM
MAIT T-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM
NK-cell: 0.2 nTPM

Brain region

choroid plexus: 1.9 nTPM
hypothalamus: 1.5 nTPM
basal ganglia: 1.4 nTPM
thalamus: 1.3 nTPM
medulla oblongata: 1.1 nTPM
midbrain: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0
gnomAD missense Z: 0.51
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

aminophospholipid flippase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM30B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM30B as an antibody target. Whether an autoantibody or antibody against TMEM30B could matter depends on whether native TMEM30B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM30B is annotated at the cell surface, where native TMEM30B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM30B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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