TMEM242
Transmembrane protein 242
Also known as: BM033, C6orf35, TM242_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NWH2
- Gene
- TMEM242
- Ensembl
- ENSG00000215712
- Chromosome
- 6
- Canonical length
- 141 aa
- Protein class
- Predicted membrane proteins, Transporters
OverviewNCBI Gene
Involved in mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
141 residues, UniProt reviewed canonical sequence.
>Q9NWH2|TMEM242
1 METAGAATGQ PASGLEAPGS TNDRLFLVKG GIFLGTVAAA GMLAGFITTL SLAKKKSPEW
61 FNKGSMATAA LPESGSSLAL RALGWGSLYA WCGVGVISFA VWKALGVHSM NDFRSKMQSI
121 FPTIPKNSES AVEWEETLKS KLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM242 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 13 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 13 nTPM
- skeletal muscle: 11 nTPM
- tongue: 11 nTPM
- cerebral cortex: 11 nTPM
- bone marrow: 10 nTPM
- blood vessel: 10 nTPM
Single-cell type
- myonuclei: 82 nCPM
- extravillous trophoblasts: 68 nCPM
- esophageal suprabasal cells: 68 nCPM
- migrating cytotrophoblasts: 66 nCPM
- cytotrophoblasts: 65 nCPM
- decidual stromal cells: 65 nCPM
Immune cell
- plasmacytoid DC: 30 nTPM
- naive B-cell: 20 nTPM
- classical monocyte: 20 nTPM
- memory B-cell: 19 nTPM
- myeloid DC: 19 nTPM
- NK-cell: 17 nTPM
Brain region
- cerebral cortex: 16 nTPM
- basal ganglia: 16 nTPM
- cerebellum: 15 nTPM
- thalamus: 15 nTPM
- hypothalamus: 15 nTPM
- hippocampal formation: 15 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.6
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.25
- DepMap mean gene effect
- -0.4
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Transmembrane protein 242
- Protein of unknown function (DUF1358)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TMEM242 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM242 as an antibody target. Whether an autoantibody or antibody against TMEM242 could matter depends on whether native TMEM242 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM242 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM242 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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