Seroatlas · Human Serome Atlas

MT-ND3

NADH-ubiquinone oxidoreductase chain 3

Also known as: MTND3, NAD3, ND3, NU3M_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P03897
Gene
MT-ND3
Ensembl
ENSG00000198840
Chromosome
MT
Canonical length
115 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Implicated in Leber hereditary optic neuropathy; Leigh disease; and Parkinson's disease. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>P03897|MT-ND3
     1  MNFALILMIN TLLALLLMII TFWLPQLNGY MEKSTPYECG FDPMSPARVP FSMKFFLVAI
    61  TFLLFDLEIA LLLPLPWALQ TTNLPLMVMS SLLLIIILAL SLAYEWLQKG LDWTE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MT-ND3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
186,830 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 186,830 nTPM
  • basal ganglia: 89,168 nTPM
  • kidney: 83,803 nTPM
  • hippocampal formation: 73,129 nTPM
  • liver: 70,972 nTPM
  • amygdala: 70,176 nTPM

Single-cell type

  • pancreatic acinar cells: 31,598 nCPM
  • hepatocytes: 22,176 nCPM
  • enterocytes: 21,790 nCPM
  • urothelial cells: 16,494 nCPM
  • endometrial glandular cells: 16,457 nCPM
  • paneth cells: 16,375 nCPM

Immune cell

  • basophil: 2,290 nTPM
  • neutrophil: 978 nTPM
  • naive CD8 T-cell: 772 nTPM
  • naive B-cell: 689 nTPM
  • memory B-cell: 675 nTPM
  • classical monocyte: 617 nTPM

Brain region

  • cerebral cortex: 52,866 nTPM
  • medulla oblongata: 50,530 nTPM
  • pons: 45,569 nTPM
  • hypothalamus: 43,577 nTPM
  • thalamus: 43,208 nTPM
  • midbrain: 41,365 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MT-ND3.

Disease | AllUniProt

Conditions MT-ND3 is implicated in, by any mechanism.

  • Leigh syndrome (LS) MIM:256000
  • Mitochondrial complex I deficiency, mitochondrial type 1 (MC1DM1) MIM:500014

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 52 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • NADH:ubiquinone/plastoquinone oxidoreductase, chain 3
  • NADH:ubiquinone oxidoreductase, subunit 3 superfamily
  • NADH-ubiquinone/plastoquinone oxidoreductase, chain 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MT-ND3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MT-ND3 as an antibody target. Whether an autoantibody or antibody against MT-ND3 could matter depends on whether native MT-ND3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MT-ND3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MT-ND3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MT-ND3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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