Seroatlas · Human Serome Atlas

SLC34A1

Sodium-dependent phosphate transport protein 2A

Also known as: NAPI-3, NPT2, NPT2A_HUMAN, NPTIIa, SLC11, SLC17A2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q06495
Gene
SLC34A1
Ensembl
ENSG00000131183
Chromosome
5
Canonical length
639 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Nuclear speckles,Plasma membrane,Mitotic spindle,Cytosol

OverviewNCBI Gene

Enables sodium:phosphate symporter activity. Involved in several processes, including phosphate ion homeostasis; response to cadmium ion; and response to lead ion. Located in several cellular components, including apical plasma membrane; mitotic spindle; and nuclear speck. Implicated in several diseases, including Fanconi syndrome (multiple); chronic kidney disease; hereditary hypophosphatemic rickets with hypercalciuria; hypophosphatemic nephrolithiasis/osteoporosis 1; and nephrolithiasis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

639 residues, UniProt reviewed canonical sequence.

>Q06495|SLC34A1
     1  MLSYGERLGS PAVSPLPVRG GHVMRGTAFA YVPSPQVLHR IPGTSAYAFP SLGPVALAEH
    61  TCPCGEVLER HEPLPAKLAL EEEQKPESRL VPKLRQAGAM LLKVPLMLTF LYLFVCSLDM
   121  LSSAFQLAGG KVAGDIFKDN AILSNPVAGL VVGILVTVLV QSSSTSTSII VSMVSSGLLE
   181  VSSAIPIIMG SNIGTSVTNT IVALMQAGDR TDFRRAFAGA TVHDCFNWLS VLVLLPLEAA
   241  TGYLHHITRL VVASFNIHGG RDAPDLLKII TEPFTKLIIQ LDESVITSIA TGDESLRNHS
   301  LIQIWCHPDS LQAPTSMSRA EANSSQTLGN ATMEKCNHIF VDTGLPDLAV GLILLAGSLV
   361  LLCTCLILLV KMLNSLLKGQ VAKVIQKVIN TDFPAPFTWV TGYFAMVVGA SMTFVVQSSS
   421  VFTSAITPLI GLGVISIERA YPLTLGSNIG TTTTAILAAL ASPREKLSSA FQIALCHFFF
   481  NISGILLWYP VPCTRLPIRM AKALGKRTAK YRWFAVLYLL VCFLLLPSLV FGISMAGWQV
   541  MVGVGTPFGA LLAFVVLINV LQSRSPGHLP KWLQTWDFLP RWMHSLKPLD HLITRATLCC
   601  ARPEPRSPPL PPRVFLEELP PATPSPRLAL PAHHNATRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC34A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
8
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
145 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 145 nTPM
  • retina: 2.6 nTPM
  • liver: 1.8 nTPM
  • skin: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • adipose tissue: 0.1 nTPM

Single-cell type

  • proximal tubule cells: 182 nCPM
  • distal convoluted tubule cells: 7.2 nCPM
  • rod photoreceptor cells: 7.1 nCPM
  • renal connecting tubule cells: 7 nCPM
  • podocytes: 6.2 nCPM
  • renal collecting duct intercalated cells: 5.2 nCPM

Immune cell

  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • cerebellum: 0 nTPM
  • hippocampal formation: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC34A1.

Disease | AllUniProt

Conditions SLC34A1 is implicated in, by any mechanism.

  • Nephrolithiasis/osteoporosis, hypophosphatemic, 1 (NPHLOP1) MIM:612286
  • Fanconi renotubular syndrome 2 (FRTS2) MIM:613388
  • Hypercalcemia, infantile, 2 (HCINF2) MIM:616963

Disease | GeneticClinVar

56 pathogenic / likely-pathogenic of 576 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hypercalcemia, infantile, 2
  • Hypophosphatemic nephrolithiasis/osteoporosis 1
  • Fanconi renotubular syndrome 2
  • SLC34A1-related disorder
  • Kidney stone

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0
gnomAD missense Z
-0.48
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC34A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC34A1 as an antibody target. Whether an autoantibody or antibody against SLC34A1 could matter depends on whether native SLC34A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC34A1 is annotated at the cell surface, where native SLC34A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC34A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC34A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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