Seroatlas · Human Serome Atlas

TMEM120A

Transmembrane protein 120A

Also known as: NET29, TACAN, TACAN_HUMAN, TMPIT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXJ8
Gene: TMEM120A
Ensembl: ENSG00000189077
Chromosome: 7
Canonical length: 343 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables coenzyme A binding activity. Involved in antiviral innate immune response; fat cell differentiation; and protein complex oligomerization. Located in endoplasmic reticulum and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>Q9BXJ8|TMEM120A
     1  MQPPPPGPLG DCLRDWEDLQ QDFQNIQETH RLYRLKLEEL TKLQNNCTSS ITRQKKRLQE
    61  LALALKKCKP SLPAEAEGAA QELENQMKER QGLFFDMEAY LPKKNGLYLS LVLGNVNVTL
   121  LSKQAKFAYK DEYEKFKLYL TIILILISFT CRFLLNSRVT DAAFNFLLVW YYCTLTIRES
   181  ILINNGSRIK GWWVFHHYVS TFLSGVMLTW PDGLMYQKFR NQFLSFSMYQ SFVQFLQYYY
   241  QSGCLYRLRA LGERHTMDLT VEGFQSWMWR GLTFLLPFLF FGHFWQLFNA LTLFNLAQDP
   301  QCKEWQVLMC GFPFLLLFLG NFFTTLRVVH HKFHSQRHGS KKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM120A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 104 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 104 nTPM
adrenal gland: 92 nTPM
tongue: 88 nTPM
liver: 80 nTPM
skeletal muscle: 72 nTPM
testis: 62 nTPM

Single-cell type

late spermatids: 1,752 nCPM
enterocytes: 383 nCPM
late primary spermatocytes: 306 nCPM
early spermatids: 280 nCPM
esophageal apical cells: 189 nCPM
breast lactating cells: 176 nCPM

Immune cell

neutrophil: 224 nTPM
eosinophil: 110 nTPM
basophil: 107 nTPM
classical monocyte: 58 nTPM
non-classical monocyte: 55 nTPM
intermediate monocyte: 54 nTPM

Brain region

pons: 85 nTPM
medulla oblongata: 55 nTPM
cerebellum: 34 nTPM
midbrain: 33 nTPM
thalamus: 30 nTPM
hypothalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM120A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM120A as an antibody target. Whether an autoantibody or antibody against TMEM120A could matter depends on whether native TMEM120A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM120A is annotated at the cell surface, where native TMEM120A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM120A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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