Seroatlas · Human Serome Atlas

TMEM120B

Transmembrane protein 120B

Also known as: T120B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0PK00
Gene: TMEM120B
Ensembl: ENSG00000188735
Chromosome: 12
Canonical length: 339 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Predicted to be involved in fat cell differentiation and protein heterooligomerization. Predicted to be located in membrane and nucleus. Predicted to be active in nuclear inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>A0PK00|TMEM120B
     1  MSGQLERCER EWHELEGEFQ ELQETHRIYK QKLEELAALQ TLCSSSISKQ KKHLKDLKLT
    61  LQRCKRHASR EEAELVQQMA ANIKERQDVF FDMEAYLPKK NGLYLNLVLG NVNVTLLSNQ
   121  AKFAYKDEYE KFKLYLTIIL LLGAVACRFV LHYRVTDEVF NFLLVWYYCT LTIRESILIS
   181  NGSRIKGWWV SHHYVSTFLS GVMLTWPNGP IYQKFRNQFL AFSIFQSCVQ FLQYYYQRGC
   241  LYRLRALGER NHLDLTVEGF QSWMWRGLTF LLPFLFCGHF WQLYNAVTLF ELSSHEECRE
   301  WQVFVLAFTF LILFLGNFLT TLKVVHAKLQ KNRGKTKQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM120B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 46 nTPM
cervix: 24 nTPM
basal ganglia: 20 nTPM
pituitary gland: 19 nTPM
fallopian tube: 17 nTPM
pancreas: 16 nTPM

Single-cell type

myonuclei: 275 nCPM
endometrial glandular cells: 267 nCPM
platelets: 177 nCPM
somatotrophs: 152 nCPM
megakaryocytes: 136 nCPM
endometrial luminal cells: 121 nCPM

Immune cell

naive B-cell: 1.1 nTPM
basophil: 0.9 nTPM
plasmacytoid DC: 0.9 nTPM
gdT-cell: 0.7 nTPM
neutrophil: 0.7 nTPM
memory B-cell: 0.6 nTPM

Brain region

cerebellum: 49 nTPM
basal ganglia: 47 nTPM
hippocampal formation: 32 nTPM
cerebral cortex: 26 nTPM
amygdala: 23 nTPM
pons: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.01
gnomAD missense Z: 0.97
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nuclear inner membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM120B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TMEM120A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM120B as an antibody target. Whether an autoantibody or antibody against TMEM120B could matter depends on whether native TMEM120B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM120B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM120B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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