Seroatlas · Human Serome Atlas

TEX28

Testis-specific protein TEX28

Also known as: CXorf2, fTEX, TEX28_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15482
Gene: TEX28
Ensembl: ENSG00000278057
Chromosome: X
Canonical length: 410 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in endomembrane system. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>O15482|TEX28
     1  MVLKAEHTRS PSATLPSNVP SCRSLSSSED GPSGPSSLAD GGLAHNLQDS VRHRILYLSE
    61  QLRVEKASRD GNTVSYLKLV SKADRHQVPH IQQAFEKVNQ RASATIAQIE HRLHQCHQQL
   121  QELEEGCRPE GLLLMAESDP ANCEPPSEKA LLSEPPEPGG EDGPVNLPHA SRPFILESRF
   181  QSLQQGTCLE TEDVAQQQNL LLQKVKAELE EAKRFHISLQ ESYHSLKERS LTDLQLLLES
   241  LQEEKCRQAL MEEQVNGRLQ GQLNEIYNLK HNLACSEERM AYLSYERAKE IWEITETFKS
   301  RISKLEMLQQ VTQLEAAEHL QSRPPQMLFK FLSPRLSLAT VLLVFVSTLC ACPSSLISSR
   361  LCTCTMLMLI GLGVLAWQRW RAIPATDWQE WVPSRCRLYS KDSGPPADGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 8.6 nTPM

Expression across tissuesHPA

Tissue

testis: 8.6 nTPM
bone marrow: 0.1 nTPM
skin: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

neutrophils: 1.6 nCPM
late spermatids: 0.8 nCPM
late primary spermatocytes: 0.5 nCPM
papillary tip epithelial cells: 0.5 nCPM
podocytes: 0.5 nCPM
early spermatids: 0.2 nCPM

Immune cell

gdT-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 0.5 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 0% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Testis-specific protein TEX28/transmembrane and coiled-coil domains protein
Predicted transmembrane and coiled-coil 2 protein
Testis-specific TEX28

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEX28 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TMCC3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX28 as an antibody target. Whether an autoantibody or antibody against TEX28 could matter depends on whether native TEX28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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