Seroatlas · Human Serome Atlas

TMC6

Transmembrane channel-like protein 6

Also known as: EVER1, EVIN1, LAK-4P, TMC6_HUMAN, TNRC6C-AS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z403
Gene
TMC6
Ensembl
ENSG00000141524
Chromosome
17
Canonical length
805 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

805 residues, UniProt reviewed canonical sequence.

>Q7Z403|TMC6
     1  MAQPLAFILD VPETPGDQGQ GPSPYDESEV HDSFQQLIQE QSQCTAQEGL ELQQREREVT
    61  GSSQQTLWRP EGTQSTATLR ILASMPSRTI GRSRGAIISQ YYNRTVQLRC RSSRPLLGNF
   121  VRSAWPSLRL YDLELDPTAL EEEEKQSLLV KELQSLAVAQ RDHMLRGMPL SLAEKRSLRE
   181  KSRTPRGKWR GQPGSGGVCS CCGRLRYACV LALHSLGLAL LSALQALMPW RYALKRIGGQ
   241  FGSSVLSYFL FLKTLLAFNA LLLLLLVAFI MGPQVAFPPA LPGPAPVCTG LELLTGAGCF
   301  THTVMYYGHY SNATLNQPCG SPLDGSQCTP RVGGLPYNMP LAYLSTVGVS FFITCITLVY
   361  SMAHSFGESY RVGSTSGIHA ITVFCSWDYK VTQKRASRLQ QDNIRTRLKE LLAEWQLRHS
   421  PRSVCGRLRQ AAVLGLVWLL CLGTALGCAV AVHVFSEFMI QSPEAAGQEA VLLVLPLVVG
   481  LLNLGAPYLC RVLAALEPHD SPVLEVYVAI CRNLILKLAI LGTLCYHWLG RRVGVLQGQC
   541  WEDFVGQELY RFLVMDFVLM LLDTLFGELV WRIISEKKLK RRRKPEFDIA RNVLELIYGQ
   601  TLTWLGVLFS PLLPAVQIIK LLLVFYVKKT SLLANCQAPR RPWLASHMST VFLTLLCFPA
   661  FLGAAVFLCY AVWQVKPSST CGPFRTLDTM YEAGRVWVRH LEAAGPRVSW LPWVHRYLME
   721  NTFFVFLVSA LLLAVIYLNI QVVRGQRKVI CLLKEQISNE GEDKIFLINK LHSIYERKER
   781  EERSRVGTTE EAAAPPALLT DEQDA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 72 nTPM
  • spinal cord: 51 nTPM
  • lymph node: 34 nTPM
  • small intestine: 31 nTPM
  • bone marrow: 28 nTPM
  • midbrain: 28 nTPM

Single-cell type

  • kupffer cells: 157 nCPM
  • oligodendrocytes: 104 nCPM
  • b-cells: 102 nCPM
  • hofbauer cells: 99 nCPM
  • breast lactating cells: 98 nCPM
  • t-cells: 95 nCPM

Immune cell

  • non-classical monocyte: 42 nTPM
  • gdT-cell: 40 nTPM
  • MAIT T-cell: 34 nTPM
  • memory CD8 T-cell: 31 nTPM
  • memory CD4 T-cell: 29 nTPM
  • intermediate monocyte: 27 nTPM

Brain region

  • white matter: 77 nTPM
  • medulla oblongata: 71 nTPM
  • midbrain: 54 nTPM
  • basal ganglia: 52 nTPM
  • cerebellum: 51 nTPM
  • pons: 49 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMC6.

Disease | AllUniProt

Conditions TMC6 is implicated in, by any mechanism.

  • Epidermodysplasia verruciformis 1 (EV1) MIM:226400

Disease | GeneticClinVar

36 pathogenic / likely-pathogenic of 899 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
0.23
DepMap mean gene effect
-0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMC6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMC6 as an antibody target. Whether an autoantibody or antibody against TMC6 could matter depends on whether native TMC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMC6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMC6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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